(2E)-(2H2)-2-Butenedioic acid

Modify Date: 2024-01-11 20:50:58

(2E)-(2H2)-2-Butenedioic acid structure	Common Name	(2E)-(2H2)-2-Butenedioic acid
	CAS Number	24461-32-3	Molecular Weight	118.085
	Density	1.5±0.1 g/cm3	Boiling Point	355.5±25.0 °C at 760 mmHg
	Molecular Formula	C₄H₂D₂O₄	Melting Point	299-300ºC (subl.)(lit.)
	MSDS	Chinese USA	Flash Point	183.0±19.7 °C
	Symbol	GHS07	Signal Word	Warning

Use of (2E)-(2H2)-2-Butenedioic acid

Fumaric acid-d2 is the deuterium labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].

Name	(E)-2,3-dideuteriobut-2-enedioic acid
Synonym	More Synonyms

Description	Fumaric acid-d2 is the deuterium labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132(3):301-8.

Description

Fumaric acid-d2 is the deuterium labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132(3):301-8.

Density	1.5±0.1 g/cm3
Boiling Point	355.5±25.0 °C at 760 mmHg
Melting Point	299-300ºC (subl.)(lit.)
Molecular Formula	C₄H₂D₂O₄
Molecular Weight	118.085
Flash Point	183.0±19.7 °C
Exact Mass	118.023514
PSA	74.60000
LogP	-0.01
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.526
Storage condition	2-8°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xi
Risk Phrases	R41;R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport

Dimethyl Fumara...

CAS#:23057-98-9

~90%

(2E)-(2H2)-2-Bu...

CAS#:24461-32-3

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 10 p. 2387 - 2392

Triphenylphosph...

CAS#:63995-70-0

2-Butynedioic acid

CAS#:142-45-0

~89%

(2E)-(2H2)-2-Bu...

CAS#:24461-32-3

tris(natrium-m-...

CAS#:98511-67-2

Literature: Tetrahedron, , vol. 46, # 18 p. 6381 - 6398

2-Butynedioic acid

CAS#:142-45-0

(2E)-(2H2)-2-Bu...

CAS#:24461-32-3

Literature: European Journal of Organic Chemistry, , # 2 p. 387 - 401

Precursor 3
CAS#:23057-98-9 Dimethyl Fumara... CAS#:63995-70-0 Triphenylphosph... CAS#:142-45-0 2-Butynedioic acid
DownStream 0

(2E)-(H)-2-Butenedioic acid

(2E)-(H)But-2-enedioic acid

2,3-dideuterio-fumaric acid

Fumaric acid-2,3-d2

2,3-2H-fumaric acid

2-Butenedioic-2,3-d acid, (2E)-

Maleic acid-2,3-d2

2,3-Dideuterio-fumarsaeure

MFCD00144378

(2E)-(2H2)-2-Butenedioic acid

Use of (2E)-(2H2)-2-Butenedioic acid

Names

(2E)-(2H2)-2-Butenedioic acid Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Precursor & DownStream

Synonyms