527-95-7

527-95-7 structure

Name: Herbacetin
Chemical Name: 3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)chromen-4-one
CAS Number: 527-95-7
Molecular Formula: C₁₅H₁₀O₇
Molecular Weight: 302.236
Catalog: Organic raw materials Organic fluorine compound Fluorobenzaldehyde series
Create Date: 2018-09-12 17:55:37
Modify Date: 2024-01-05 16:51:34
Herbacetin is a natural flavonoid from flaxseed, exerts various pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects[1]. Herbacetin is an Ornithine decarboxylase (ODC) allosteric inhibitor, directly binds to Asp44, Asp243, and Glu384 on ODC. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis[2].

Name	3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)chromen-4-one
Synonyms	3,5,7,8-Tetrahydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one 8-Hydroxykaempferol 4H-1-Benzopyran-4-one, 3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)- Herbacetin 3,4',5,7,8-Pentahydroxyflavone 3,4´,5,7,8-pentahydroxyflavone 3,5,7,8,4'-pentahydroxyflavone

Description	Herbacetin is a natural flavonoid from flaxseed, exerts various pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects[1]. Herbacetin is an Ornithine decarboxylase (ODC) allosteric inhibitor, directly binds to Asp44, Asp243, and Glu384 on ODC. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: Ornithine decarboxylase[2]
In Vivo	Herbacetin (orally administration; 20mg/kg) significantly reduces the body weight, plasma glucose, plasma insulin, and HOMA-IR activity in obesity associated insulin resistant mice (OIR). (Herbacetin dissolves in 0.5% DMSO)[1]. Herbacetin (intraperitoneal injection; 0.4, 2, 10 or 20 mg/kg; B.W.) decreases the number and size of polyps in APCMin+ mice with no overt toxicity[2].
References	[1]. Veeramani C, et al. Herbacetin, a flaxseed flavonoid, ameliorates high percent dietary fat induced insulin resistance and lipid accumulation through the regulation of hepatic lipid metabolizing and lipid-regulating enzymes. Chem Biol Interact. 2018 May 25;288:49-56. [2]. Kim DJ, et al. Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity. Cancer Res. 2016 Mar 1;76(5):1146-1157.

HS Code	2914501900
Summary	2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%