52886-37-0

52886-37-0 structure

Name: Deoxycholic acid-13C
Chemical Name: (4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
CAS Number: 52886-37-0
Molecular Formula: C₂₄H₄₀O₄
Molecular Weight: 393.565
Create Date: 2016-06-25 04:53:29
Modify Date: 2024-01-09 18:01:29
Deoxycholic acid-13C (Cholanoic acid-13C) is the 13C-labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

Name	(4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
Synonyms	Cholan-24-oic-24-C acid, 3,12-dihydroxy-, (3α,5β,12α)- 3a,12a-Dihydroxy-5\|A-cholanic acid-24-13C Cholan-24-oic-24-C acid, 3,12-dihydroxy-, (3α,5β,12β)- 7-Deoxycholic acid-24-13C (3α,5β,12β)-3,12-Dihydroxy(24-C)cholan-24-oic acid <24-13C>-Deoxycholsaeure Deoxycholic acid-24-13C Desoxycholic acid-24-13C (3α,5β,12α)-3,12-Dihydroxy(24-C)cholan-24-oic acid 3a,12a-Dihydroxy-5ß-cholanic acid-24-13C,7-Deoxycholic acid-24-13C,Desoxycholic acid-24-13C

Description	Deoxycholic acid-13C (Cholanoic acid-13C) is the 13C-labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GPCR19 Research Areas >> Metabolic Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Somm E, et al. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. JCI Insight. 2017 Apr 20;2(8). pii: 91809. [3]. Wang X, et al. Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in micedependent on c-Myc expression. Cancer Med. 2017 Apr;6(4):788-797.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
RIDADR	NONH for all modes of transport