5534-18-9

5534-18-9 structure

Name: Beclomethasone 17-Propionate
Chemical Name: Beclomethasone 17-Propionate
CAS Number: 5534-18-9
Molecular Formula: C₂₅H₃₃ClO₆
Molecular Weight: 464.97900
Catalog: Signaling Pathways GPCR/G Protein Glucocorticoid Receptor
Create Date: 2018-12-06 13:25:59
Modify Date: 2026-07-10 08:02:04
Beclomethasone 17-propionate (Beclomethasone-17-monopropionate), an active metabolite of Beclomethasone dipropionate (HY-13571), is a glucocorticoid receptor (GR) agonist. Beclomethasone 17-propionate exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in chronic obstructive pulmonary disease (COPD) lung macrophages[1][2][3].

Name	Beclomethasone 17-Propionate
Synonyms	D5-Beclomethasone 17-Propionate Beclometasone Dipropionate Imp. H : (11β,16β)-9-Chloro-11,21-dihydroxy-16-methyl-17-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione beclomethasone 17-monopropionate Beclomethasone Impurity H 17-BMP Beclomethasone-17-PropionateQ: What is Beclomethasone-17-Propionate Q: What is the CAS Number of Beclomethasone-17-Propionate Q: What is the storage condition of Beclomethasone-17-Propionate Q: What e the applications of Beclomethasone-17-Propionate 9-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 17-propanoate Pregna-1,4-diene-3,20-dione, 9-chloro-11,21-dihydroxy-16-methyl-17-(1-oxopropoxy)-, (11β,16β) 9-Chloro-11β-hydroxy-16β-methyl-17α-(propionyloxy)-21-hydroxypregna-1,4-diene-3,20-dione BECLOMETHASONE 17-MONO PROPIOTE 9-Chloro-11β,21-dihydroxy-16β-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione 9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate Beclomethasone Dipropionate impurity 5/Beclomethasone Dipropionate Impurity H/Beclomethasone-17-monopropionate Beclomethasone-17-Propionate D5Q: What is Beclomethasone-17-Propionate D5 Q: What is the CAS Number of Beclomethasone-17-Propionate D5 Q: What is the storage condition of Beclomethasone-17-Propionate D5 Q: What e the applications of Beclomethasone-17-Propionate D5 (8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate 9-chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate (8S,9R,10S,11S,13S,14S,16S,17R)-9-Chloro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propanoate 9-Chloro-11beta,21-dihydroxy-16beta-methyl-3,20-dioxopregna-1,4-dien-17-yl Propanoate (Beclometasone Beclomethasone Dipropionate Impurity H (Beclomethasone-17-monopropionate) 1, 4-PREGNADIEN-9α-CHLORO-16β-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE 17-PROPIONATE 9-Chloro-11beta,21-dihydroxy-16beta-methyl-3,20-dioxopregna-1,4-dien-17-yl Propanoate (Beclometasone 17-Propionate) Beclometasone (Beclomethasone) Dipropionate Impurity H (Beclomethasone Dipropionate Related Compound H, Beclomethasone-17-Monopropionate) 9-Chloro-11beta,21-dihydroxy-16beta 9-Chloro-11,21-dihydroxy-16-methyl-17-propionyloxypregna-1,4-diene-3,20-dione Beclometasone Dipropionate Related Compound H Beclometasone Propionate Impurity H BECLOMETHASONE 17-PROPIONATE Beclometasone Impurity 15 [(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate Beclomethasone Impurity 7(Beclometasone Dipropionate Impurity H) Beclometasone Dipropionate Impurity H Beclomethasone-17-monopropionate reference substance Beclomethasone Propionate Impurity H Beclomethasone Impurity 2 Beclomethasone Dipropionate Impurity H (11,16)-9-Chloro-11,21-dihydroxy-16-methyl-17-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione

Description	Beclomethasone 17-propionate (Beclomethasone-17-monopropionate), an active metabolite of Beclomethasone dipropionate (HY-13571), is a glucocorticoid receptor (GR) agonist. Beclomethasone 17-propionate exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in chronic obstructive pulmonary disease (COPD) lung macrophages[1][2][3].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
In Vitro	Metabolism of Beclomethasone dipropionate to 17-BMP is an important activation step. Beclomethasone 17-propionate inhibits LPS-stimulated CXCL8, TNFα and IL-6. The EC50 values of Beclomethasone 17-propionate for IL-6, TNFα and CXCL8 were 0.05 nM, 0.01 nM and 0.1 nM, respectively. Beclomethasone 17-propionate evokes upregulation of the GR dependent genes FKBP51 and GILZ[3].
References	[1]. Würthwein G, et al. Activation of beclomethasone dipropionate by hydrolysis to beclomethasone-17-monopropionate. Biopharm Drug Dispos. 1990 Jul;11(5):381-94. [2]. Roberts JK, et al. Metabolism of beclomethasone dipropionate by cytochrome P450 3A enzymes. J Pharmacol Exp Ther. 2013 May;345(2):308-16. [3]. Plumb J, et al. Evaluation of glucocorticoid receptor function in COPD lung macrophages using beclomethasone-17-monopropionate. PLoS One. 2013 May 21;8(5):e64257.

Density	1.3g/cm3
Boiling Point	608.9ºC at 760mmHg
Melting Point	124-126ºC
Molecular Formula	C₂₅H₃₃ClO₆
Molecular Weight	464.97900
Flash Point	322ºC
Exact Mass	464.19700
PSA	100.90000
LogP	3.12590
Index of Refraction	1.583
Storage condition	-20°C

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