5534-18-9

• 常用中文名：倍氯米松17-丙酸酯
• 常用英文名：Beclomethasone 17-Propionate
• CAS号：5534-18-9
• 分子式：C₂₅H₃₃ClO₆
• 分子量：464.97900
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 糖皮质激素受体
• 发布时间：2018-12-06 13:25:59
• 更新时间：2026-07-10 08:02:04
• Beclomethasone 17-propionate (Beclomethasone-17-monopropionate) 是 Beclomethasone dipropionate (HY-13571) 的活性代谢产物,是糖皮质激素受体 (GR) 激动剂。Beclomethasone 17-propionate 对 GR 的亲和力比 Beclomethasone dipropionate 高。Beclomethasone 17-propionate 有效抑制慢性阻塞性肺疾病 (COPD) 肺巨噬细胞中细胞因子的产生。

名称

• 中文名: 9Alpha-氯-16Β-甲基孕甾-1,4-二烯-11Β,17Alpha,21-三醇-3,20-二酮-17-丙酸酯
• 英文名: Beclomethasone 17-Propionate
• 中文别名: 二丙酸倍氯米松杂质H(17-单丙酸倍氯米松); 倍氯米松-17-丙酸; 倍氯米松17-丙酸盐; (8S,9R,10S,11S,13S,14S,16S,17R)-9-氯-11-羟基-17-(2-羟基乙酰基)-10,13,16-三甲基-3-氧代-6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环庚烷并[a]菲-17-基 丙酸酯; 倍氯米松杂质7(BECLOMETASONEDIPROPIONATE杂质H); 氯地米松-17 - 单丙酸酯; 倍氯米松17-单丙酸盐; 9Α-氯-16Β-甲基孕甾-1,4-二烯-11Β,17Α,21-三醇-3,20-二酮-17-丙酸酯; 倍氯米松双丙酸酯杂质H(倍氯米松17-单丙酸酯); 倍氯米松17-单丙酸酯-D5; 丙酸倍氯米松杂质H; 二丙酸倍氯米松相关化合物H; 氘5-倍氯米松17-丙酸酯; 倍氯米松(倍氯米松)二丙酸酯 杂质 H(倍氯米松二丙酸酯 相关化合物 H,BECLOMETHASONE-17-MONOPROPIONATE); 倍氯米松-17-单丙酸酯对照品; 倍氯米松双丙酸酯杂质H; 倍氯米松杂质H; 倍氯米松 17-丙酸酯; 二丙酸倍氯米松杂质H; 丙酸倍氯米松杂质H 标准品; 9ALPHA-氯-16Β-甲基孕甾-1,4-二烯-11Β,17ALPHA,21-三醇-3,20-二酮-17-丙酸酯; 倍氯米松杂质7(丙酸倍氯米松杂质H)
• 英文别名: D5-Beclomethasone 17-Propionate; Beclometasone Dipropionate Imp. H : (11β,16β)-9-Chloro-11,21-dihydroxy-16-methyl-17-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione; beclomethasone 17-monopropionate; Beclomethasone Impurity H; 17-BMP; Beclomethasone-17-PropionateQ: What is Beclomethasone-17-Propionate Q: What is the CAS Number of Beclomethasone-17-Propionate Q: What is the storage condition of Beclomethasone-17-Propionate Q: What e the applications of Beclomethasone-17-Propionate; 9-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 17-propanoate; Pregna-1,4-diene-3,20-dione, 9-chloro-11,21-dihydroxy-16-methyl-17-(1-oxopropoxy)-, (11β,16β); 9-Chloro-11β-hydroxy-16β-methyl-17α-(propionyloxy)-21-hydroxypregna-1,4-diene-3,20-dione; BECLOMETHASONE 17-MONO PROPIOTE; 9-Chloro-11β,21-dihydroxy-16β-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione; 9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate; Beclomethasone Dipropionate impurity 5/Beclomethasone Dipropionate Impurity H/Beclomethasone-17-monopropionate; Beclomethasone-17-Propionate D5Q: What is Beclomethasone-17-Propionate D5 Q: What is the CAS Number of Beclomethasone-17-Propionate D5 Q: What is the storage condition of Beclomethasone-17-Propionate D5 Q: What e the applications of Beclomethasone-17-Propionate D5; (8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate; 9-chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate; (8S,9R,10S,11S,13S,14S,16S,17R)-9-Chloro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propanoate; 9-Chloro-11beta,21-dihydroxy-16beta-methyl-3,20-dioxopregna-1,4-dien-17-yl Propanoate (Beclometasone; Beclomethasone Dipropionate Impurity H (Beclomethasone-17-monopropionate); 1, 4-PREGNADIEN-9α-CHLORO-16β-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE 17-PROPIONATE; 9-Chloro-11beta,21-dihydroxy-16beta-methyl-3,20-dioxopregna-1,4-dien-17-yl Propanoate (Beclometasone 17-Propionate); Beclometasone (Beclomethasone) Dipropionate Impurity H (Beclomethasone Dipropionate Related Compound H, Beclomethasone-17-Monopropionate); 9-Chloro-11beta,21-dihydroxy-16beta; 9-Chloro-11,21-dihydroxy-16-methyl-17-propionyloxypregna-1,4-diene-3,20-dione; Beclometasone Dipropionate Related Compound H; Beclometasone Propionate Impurity H; BECLOMETHASONE 17-PROPIONATE; Beclometasone Impurity 15; [(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate; Beclomethasone Impurity 7(Beclometasone Dipropionate Impurity H); Beclometasone Dipropionate Impurity H; Beclomethasone-17-monopropionate reference substance; Beclomethasone Propionate Impurity H; Beclomethasone Impurity 2; Beclomethasone Dipropionate Impurity H; (11,16)-9-Chloro-11,21-dihydroxy-16-methyl-17-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione

物化性质

• 密度: 1.3g/cm3
• 沸点: 608.9ºC at 760mmHg
• 熔点: 124-126ºC
• 分子式: C₂₅H₃₃ClO₆
• 分子量: 464.97900
• 闪点: 322ºC
• 精确质量: 464.19700
• PSA: 100.90000
• LogP: 3.12590
• 折射率: 1.583
• 储存条件: -20°C

生物活性

• 描述: Beclomethasone 17-propionate (Beclomethasone-17-monopropionate) 是 Beclomethasone dipropionate (HY-13571) 的活性代谢产物,是糖皮质激素受体 (GR) 激动剂。Beclomethasone 17-propionate 对 GR 的亲和力比 Beclomethasone dipropionate 高。Beclomethasone 17-propionate 有效抑制慢性阻塞性肺疾病 (COPD) 肺巨噬细胞中细胞因子的产生。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体
• 体外研究: 丙酸倍氯米松对17-BMP的代谢是一个重要的活化步骤。丙酸倍氯米松抑制LPS刺激的CXCL8、TNFα和IL-6。丙酸倍氯米松对IL-6、TNFα和CXCL8的EC50值分别为0.05nm、0.01nm和0.1nm。丙酸倍氯米松引起GR依赖基因FKBP51和GILZ的上调[3]。
• 参考文献:

  [1]. Würthwein G, et al. Activation of beclomethasone dipropionate by hydrolysis to beclomethasone-17-monopropionate. Biopharm Drug Dispos. 1990 Jul;11(5):381-94.

  [2]. Roberts JK, et al. Metabolism of beclomethasone dipropionate by cytochrome P450 3A enzymes. J Pharmacol Exp Ther. 2013 May;345(2):308-16.

  [3]. Plumb J, et al. Evaluation of glucocorticoid receptor function in COPD lung macrophages using beclomethasone-17-monopropionate. PLoS One. 2013 May 21;8(5):e64257.