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56472-29-8

56472-29-8 structure
56472-29-8 structure
  • Name: Minerval
  • Chemical Name: 2-Hydroxy Oleic Acid
  • CAS Number: 56472-29-8
  • Molecular Formula: C18H34O3
  • Molecular Weight: 298.46100
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2017-02-02 10:33:29
  • Modify Date: 2024-01-02 22:57:02
  • Minerval (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. Minerval has anti-tumor effect[1].
Name 2-Hydroxy Oleic Acid
Synonyms (Z)-2-hydroxyoctadec-9-enoic acid
Description Minerval (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. Minerval has anti-tumor effect[1].
Related Catalog
In Vitro Minerval (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC50 of ~40 μM[1]. Minerval (25-50 μM; 72 hours) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis[1]. Cell Viability Assay[1] Cell Line: Jurkat cells Concentration: 25 μM, 50 μM, 75 μM Incubation Time: 24 hours, 48 hours, 72 hours Result: Impaired Jurkat cell growth in a time- and concentration-dependent manner. Western Blot Analysis[1] Cell Line: Jurkat cells Concentration: 25 μM, 50 μM Incubation Time: 72 hours Result: Induced a marked and concentration-dependent increase in the proteolytic cleavage of PARP.
In Vivo Minerval markedly and significantly inhibits tumour growth in nude mice infected with Jurkat cells[1]. Animal Model: 6-week-old nude male mice (Jurkat cells xenograft model)[1] Dosage: 600 mg/kg Administration: Oral administration; daily; for 21 days Result: Markedly and significantly inhibited tumour growth.
References

[1]. Llado V, et al. Minerval induces apoptosis in Jurkat and other cancer cells. J Cell Mol Med. 2010 Mar;14(3):659-70.
Molecular Formula C18H34O3
Molecular Weight 298.46100
Exact Mass 298.25100
PSA 57.53000
LogP 5.07930
Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H318
Precautionary Statements P280-P305 + P351 + P338
Hazard Codes C
Safety Phrases 26-39
RIDADR NONH for all modes of transport
112-80-1 structure

112-80-1

~%

56472-29-8 structure

56472-29-8

Literature: Adam, Waldemar; Lazarus, Michael; Schmerder, Alexandra; Humpf, Hans-Ulrich; Saha-Moeller, Chantu R.; Schreier, Peter European Journal of Organic Chemistry, 1998 , # 9 p. 2013 - 2018
Precursor  1

DownStream  1


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