874908-14-2

874908-14-2 structure

Name: 3'-Hydroxy Repaglinide
Chemical Name: 2-ethoxy-4-[2-[[1-[2-(3-hydroxypiperidin-1-yl)phenyl]-3-methylbutyl]amino]-2-oxoethyl]benzoic acid
CAS Number: 874908-14-2
Molecular Formula: C₂₇H₃₆N₂O₅
Molecular Weight: 468.58500
Catalog: Research Areas Metabolic Disease
Create Date: 2018-12-07 04:27:26
Modify Date: 2024-01-10 23:53:04
3'-Hydroxy Repaglinide is a main CYP2C8 metabolite of Repaglinide. Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes[1][2].

Name	2-ethoxy-4-[2-[[1-[2-(3-hydroxypiperidin-1-yl)phenyl]-3-methylbutyl]amino]-2-oxoethyl]benzoic acid

Description	3'-Hydroxy Repaglinide is a main CYP2C8 metabolite of Repaglinide. Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes[1][2].
Related Catalog	Research Areas >> Metabolic Disease
References	[1]. A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probedrugs and their corresponding metabolites in human serum and urine. Anal Bioanal Chem. 2017 Jan;409(1):251-268. [2]. Honkalammi J, et al. Mechanism-based inactivation of CYP2C8 by gemfibrozil occurs rapidly in humans. Clin Pharmacol Ther. 2011 Apr;89(4):579-86.