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135-16-0

135-16-0 structure
135-16-0 structure
  • Name: L-5,6,7,8-Tetrahydrofolic acid
  • Chemical Name: 5,6,7,8-tetrahydrofolic acid
  • CAS Number: 135-16-0
  • Molecular Formula: C19H23N7O6
  • Molecular Weight: 445.42900
  • Catalog: API Vitamins and minerals Vitamin C drugs
  • Create Date: 2018-04-21 08:00:00
  • Modify Date: 2024-01-02 14:19:56
  • L-5,6,7,8-Tetrahydrofolic acid, a folic acid derivative, which is a coenzyme in many reactions, especially in the metabolism of amino acids and nucleic acids.
Name 5,6,7,8-tetrahydrofolic acid
Synonyms Tetrahydrofolic acide
Tetrahydropteroylglutaamic acid
(6S)-Tetrahydrofolic acid
l-amino)benzoyl)
TETRAHYDROFOLIC ACID
EINECS 205-181-1
5,6,7,8-tetrahydrofolicacid
L-5,6,7,8-Tetrahydrofolic acid
MFCD00135583
(6S)-Thfa
tetrahydropteroylglutamicacid
(6R,6S)-tetrahydrofolic acid
(6RS)-5,6,7,8-Tetrahydro-L-folsaeure
Description L-5,6,7,8-Tetrahydrofolic acid, a folic acid derivative, which is a coenzyme in many reactions, especially in the metabolism of amino acids and nucleic acids.
Related Catalog
Target

Human Endogenous Metabolite

Density 1.7g/cm3
Boiling Point 555.12°C (rough estimate)
Molecular Formula C19H23N7O6
Molecular Weight 445.42900
Exact Mass 445.17100
PSA 211.56000
LogP 1.03910
Appearance powder | off-white to tan
Index of Refraction 1.762
Storage condition −20°C
Stability We have observed that this material decomposes steadily over time. Use immediately upon receipt.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MA0600800
CHEMICAL NAME :
Glutamic acid, N-(p-(((2-amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridi nyl)methyl)amino) benzoyl)-, L-
CAS REGISTRY NUMBER :
135-16-0
LAST UPDATED :
199707
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C19-H23-N7-O6
MOLECULAR WEIGHT :
445.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
18 gm/kg/5W-I
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - normocytic anemia
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1104,1973
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6 gm/kg/6D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight Related to Chronic Data - death
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1128,1973
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
46800 mg/kg/26W-I
TOXIC EFFECTS :
Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1114,1973 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
70 mg/kg
SEX/DURATION :
female 8-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - physical
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1132,1973
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
70 mg/kg
SEX/DURATION :
female 7-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1132,1973
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS MA0600800
HS Code 2933990090
59-30-3 structure

59-30-3

~57%

135-16-0 structure

135-16-0

Literature: Zhou, Minghao; Hong, Mei; Xiao, Guomin Research on Chemical Intermediates, 2013 , vol. 39, # 5 p. 2211 - 2218
15574-38-6 structure

15574-38-6

~%

135-16-0 structure

135-16-0

Literature: Antimicrobial Agents and Chemotherapy, , vol. 57, # 10 p. 4990 - 4998
4033-27-6 structure

4033-27-6

~69%

135-16-0 structure

135-16-0

Literature: Charlton, Peter A.; Young, Douglas W.; Birdsall, Berry; Feeney, James; Roberts, Gordon C. K. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1349 - 1354
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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title: CAS No. 135-16-0 | Chemsrc address: https://m.chemsrc.com/en/baike/692229.html

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