L-5,6,7,8-Tetrahydrofolic acid

Modify Date: 2026-07-01 17:32:54

L-5,6,7,8-Tetrahydrofolic acid structure	Common Name	L-5,6,7,8-Tetrahydrofolic acid
	CAS Number	135-16-0	Molecular Weight	445.42900
	Density	1.7g/cm3	Boiling Point	555.12°C (rough estimate)
	Molecular Formula	C₁₉H₂₃N₇O₆	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of L-5,6,7,8-Tetrahydrofolic acid

L-5,6,7,8-Tetrahydrofolic acid, a folic acid derivative, which is a coenzyme in many reactions, especially in the metabolism of amino acids and nucleic acids.

Name	5,6,7,8-tetrahydrofolic acid
Synonym	More Synonyms

Description	L-5,6,7,8-Tetrahydrofolic acid, a folic acid derivative, which is a coenzyme in many reactions, especially in the metabolism of amino acids and nucleic acids.
Related Catalog	Natural Products >> Others Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite

Density	1.7g/cm3
Boiling Point	555.12°C (rough estimate)
Molecular Formula	C₁₉H₂₃N₇O₆
Molecular Weight	445.42900
Exact Mass	445.17100
PSA	211.56000
LogP	1.03910
Appearance of Characters	powder \| off-white to tan
Index of Refraction	1.762
InChIKey	MSTNYGQPCMXVAQ-KIYNQFGBSA-N
SMILES	Nc1nc2c(c(=O)[nH]1)NC(CNc1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1)CN2
Storage condition	−20°C
Stability	We have observed that this material decomposes steadily over time. Use immediately upon receipt.

L-5,6,7,8-Tetrahydrofolic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA0600800

CHEMICAL NAME :: Glutamic acid, N-(p-(((2-amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridi nyl)methyl)amino) benzoyl)-, L-

CAS REGISTRY NUMBER :: 135-16-0

LAST UPDATED :: 199707

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C19-H23-N7-O6

MOLECULAR WEIGHT :: 445.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18 gm/kg/5W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - normocytic anemia

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1104,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6 gm/kg/6D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight Related to Chronic Data - death

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1128,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 46800 mg/kg/26W-I

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1114,1973 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 70 mg/kg

SEX/DURATION :: female 8-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - physical

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1132,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 70 mg/kg

SEX/DURATION :: female 7-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1132,1973

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	MA0600800
HS Code	2933990090

Folic Acid

CAS#:59-30-3

~57%

L-5,6,7,8-Tetra...

CAS#:135-16-0

Learn More

Literature: Zhou, Minghao; Hong, Mei; Xiao, Guomin Research on Chemical Intermediates, 2013 , vol. 39, # 5 p. 2211 - 2218

CAS#:15574-38-6

L-5,6,7,8-Tetra...

CAS#:135-16-0

Learn More

Literature: Antimicrobial Agents and Chemotherapy, , vol. 57, # 10 p. 4990 - 4998

Dihydrofolic acid

CAS#:4033-27-6

~69%

L-5,6,7,8-Tetra...

CAS#:135-16-0

Learn More

Literature: Charlton, Peter A.; Young, Douglas W.; Birdsall, Berry; Feeney, James; Roberts, Gordon C. K. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1349 - 1354

Precursor 2
CAS#:59-30-3 Folic Acid CAS#:4033-27-6 Dihydrofolic acid
DownStream 4
CAS#:28459-40-7 10-Formyl-7,8-d... CAS#:72973-87-6 2-[[4-[(2-amino... CAS#:72973-88-7 2-[[4-[[2-amino... CAS#:72988-03-5 L-Glutamicacid,...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Quantitation of 5-Methyltetrahydrofolic Acid in Dried Blood Spots and Dried Plasma Spots by Stable Isotope Dilution Assays.

PLoS ONE 10 , e0143639, (2015)

Because of minimal data available on folate analysis in dried matrix spots (DMSs), we combined the advantages of stable isotope dilution assays followed by LC-MS/MS analysis with DMS sampling to devel...

Arg-265: a critical residue of L.donovani cytosolic SHMT in maintaining the binding of THF and catalysis.

Exp. Parasitol. 149 , 16-23, (2015)

Serine hydroxymethyltransferase belongs to the class of pyridoxal-5-phosphate enzymes along with aspartate aminotransferase. To explore the function of residue(s) involved in binding of the carboxylat...

Folate levels measured by LC-MS/MS in patients with colorectal cancer treated with different leucovorin dosages.

Cancer Chemother. Pharmacol. 74(6) , 1167-74, (2014)

Calcium folinate (leucovorin), which is converted in vivo into biologically active folate, enhances the potency of 5-fluorouracil (5-FU)-based chemotherapy in colorectal cancer. A common dosage of leu...

Name: Dissociation rate constant of compound for wild type Escherichia coli dihydrofolate r...
Source: ChEMBL
Target: Dihydrofolate reductase
External Id: CHEMBL668112

Name: Inhibition of human sclerostin expressed in MC3T3-E1 cells co-transfected with Wnt1 a...
Source: ChEMBL
Target: Sclerostin
External Id: CHEMBL5502139

Name: Inhibition of human sclerostin expressed in MC3T3-E1 cells co-transfected with Wnt1 a...
Source: ChEMBL
Target: Sclerostin
External Id: CHEMBL5502138

Name: Inhibition of human sclerostin mediated suppressive effect on Wnt1 signaling expresse...
Source: ChEMBL
Target: Sclerostin
External Id: CHEMBL5502137

Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582

Name: Binding affinity to SOST loop3 (unknown origin) by SPR analysis
Source: ChEMBL
Target: Sclerostin
External Id: CHEMBL5502134

Name: Binding affinity to SOST loop2 (unknown origin) by SPR analysis
Source: ChEMBL
Target: Sclerostin
External Id: CHEMBL5502133

Name: Binding affinity to SOST (unknown origin) by SPR analysis
Source: ChEMBL
Target: Sclerostin
External Id: CHEMBL5502132

Name: Rate of hydride transfer (E-N) of compound for mutant T46A Escherichia coli dihydrofo...
Source: ChEMBL
Target: Dihydrofolate reductase
External Id: CHEMBL664036

Name: Rate of hydride transfer (E-N) of compound for mutant T46N Escherichia coli dihydrofo...
Source: ChEMBL
Target: Dihydrofolate reductase
External Id: CHEMBL664037

Total 27, Current Page 1 of 3

Tetrahydrofolic acide

Tetrahydropteroylglutaamic acid

(6S)-Tetrahydrofolic acid

l-amino)benzoyl)

TETRAHYDROFOLIC ACID

EINECS 205-181-1

5,6,7,8-tetrahydrofolicacid

L-5,6,7,8-Tetrahydrofolic acid

MFCD00135583

(6S)-Thfa

tetrahydropteroylglutamicacid

(6R,6S)-tetrahydrofolic acid

(6RS)-5,6,7,8-Tetrahydro-L-folsaeure

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: L-5,6,7,8-Tetrahydrofolic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: L-Glutamic acid,N-[4-[[(2-amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Price: ￥867.6/100mg

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L-5,6,7,8-Tetrahydrofolic acid

Use of L-5,6,7,8-Tetrahydrofolic acid

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