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57757-57-0

57757-57-0 structure
57757-57-0 structure
  • Name: DSP Crosslinker
  • Chemical Name: 3,3'-dithiodipropionic acid di(n-succinimidyl ester)
  • CAS Number: 57757-57-0
  • Molecular Formula: C14H16N2O8S2
  • Molecular Weight: 404.415
  • Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
  • Create Date: 2018-12-25 15:33:24
  • Modify Date: 2024-01-11 22:50:21
  • DSP Crosslinker is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs)[1].

Name 3,3'-dithiodipropionic acid di(n-succinimidyl ester)
Synonyms 2,5-Pyrrolidinedione, 1,1'-[dithiobis[(1-oxo-3,1-propanediyl)oxy]]bis-
DSP
1,1'-{Disulfanediylbis[(1-oxopropane-3,1-diyl)oxy]}dipyrrolidine-2,5-dione
MFCD00042045
1-((3-((3-((2,5-Dioxo-1-pyrrolidinyl)oxy)-3-oxopropyl)dithio)propanoyl)oxy)-2,5-pyrrolidinedione
Di(N-succinimidyl) 3,3'-dithiodipropionate
dithiobis(succinimidyl propionate)
2,5-Pyrrolidinedione, 1,1'-(dithiobis((1-oxo-3,1-propanediyl)oxy))bis-
1,1'-{Disulfanediylbis[(1-oxo-3,1-propanediyl)oxy]}di(2,5-pyrrolidinedione)
(2,5-dioxopyrrolidin-1-yl) 3-[[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropyl]disulfanyl]propanoate
EINECS 260-931-5
Description DSP Crosslinker is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog
Target

Cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References

[1]. Zorea J, et al. Probing antibody surface density and analyte antigen incubation time as dominant parameters influencing the antibody-antigen recognition events of a non-faradaic and diffusion-restricted electrochemical immunosensor. Anal Bioanal Chem. 2020 Mar;412(7):1709-1717.

Density 1.6±0.1 g/cm3
Boiling Point 560.1±60.0 °C at 760 mmHg
Melting Point 128-133 °C
Molecular Formula C14H16N2O8S2
Molecular Weight 404.415
Flash Point 292.6±32.9 °C
Exact Mass 404.034790
PSA 177.96000
LogP -1.66
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.625
Storage condition 2-8°C
Water Solubility chloroform: 50 mg/mL
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2930909090
Precursor  3

DownStream  0

HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%