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57757-57-0

57757-57-0 structure

57757-57-0 structure

Name: DSP Crosslinker
Chemical Name: 3,3'-dithiodipropionic acid di(n-succinimidyl ester)
CAS Number: 57757-57-0
Molecular Formula: C₁₄H₁₆N₂O₈S₂
Molecular Weight: 404.415
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2018-12-25 15:33:24
Modify Date: 2026-06-29 18:30:07
DSP Crosslinker is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs)[1].

Name	3,3'-dithiodipropionic acid di(n-succinimidyl ester)
Synonyms	3,3'-dithiodipropionic acid di(N-succinimidyl ester) 3,3'-DITHIODIPROPIONIC ACID DI-(N-HYDROXY-SUCCINIMIDE ESTER) 3,3'-Dithiobis(propanoic acid 2,5-dioxo-1-pyrrolidinyl) ester Di(N-succinimidyl) 3,3μ-dithiodipropionate, Dithiobis(succinimidyl propionate), DTSP, Lomants 3,3'-DITHIO-BIS(PROPIONIC ACID N-HYDROXY SUCCINIMID 3,3'-DITHIOPROPIONIC ACID DI(N-SUCCINIMIDYL ESTER) LOMANTS 1-((3-((3-((2,5-Dioxo-1-pyrrolidinyl)oxy)-3-oxopropyl)dithio)propanoyl)oxy)-2,5-pyrrolidinedione 3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester)(DSP) DSS, WATER-SOLUBLE 3,3'-DITHIOBIS(SUCCINIMIDYL PROPIONATE) DSP DSP Crosslinker, 10 mM in DMSO 3,3'-Dithiobis(propanoic acid succinimidyl) ester DSP3,3'-dithiobis-, 1,1'-bis(2,5-dioxo-1-pyrrolidinyl) ester Dithio-bis-succinimidyl propionate (Lomant''s ) LOMANT'S Di(N-succinimidyl)3,3'-Dithiodipropionate[Cross-linkineagent]> 1,1'-{Disulfanediylbis[(1-oxo-3,1-propanediyl)oxy]}di(2,5-pyrrolidinedione) Di(N-succinimidyl) 3,3'-Dithiodipropionate [Cross-linking ] 3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester),DTSP, Di(N-succinimidyl) 3,3′-dithiodipropionate, Dithiobis(succinimidyl propionate), Lomant’s 3,3'-dithiopropionic acid bis(N-hydroxysuccinimide ester) DSP (dithiobis(succinimidyl propionate)), Lomant's 1,1'-[Dithiobis[(1-oxo-3,1-propanediyl)oxy]]bis(2,5-pyrrolidinedione) Dithio-bis-succinimidyl propionate(DTSP) 3,3'-DITHIO-BIS(PROPIONIC ACID N-HYDROXYSUCCINIMIDE ESTER) 3,3'-Dithiodipropionic acid bis(2,5-dioxopyrrolidine-1-yl) ester disuccinimido dithiobispropionate Bis(2,5-dioxopyrrolidin-1-yl) 3,3'-disulfanediyldipropanoate DSP 3,3'-dithiobis-, 1,1'-bis(2,5-dioxo-1-pyrrolidinyl) ester 3,3'-dithiobispropanoic acid bis(N-hydroxysucciniMde ester) 1,1'-[Dithiobis[(1-oxo-3,1-propanediyl)oxy]]bis-2,5-pyrrolidinedione, Bis[2-[(succiniMidyloxy)carbonyl]ethyl] disulfide DITHIOBIS(SUCCINIMIDYL PROPIONATE) (2,5-dioxopyrrolidin-1-yl) 3-[[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropyl]disulfanyl]propanoate 3,3'-DITHIODIPROPIONIC ACID BIS(N-SUCCINIMIDYL ESTER) Di(N-succinimidyl) 3,3'-dithiodipropionate (DTSP):Dithio-bis-succinimidyl propionate 3,3-dithio-bis(propionic acid N-*hydroxysuccinim 3,3-DITHIODIPROPIONIC ACID DI(N-SUCCINIMIDYL ESTER)[CROSS-LINKING ] Propanoic acid, 3,3'-dithiobis-, 1,1'-bis(2,5-dioxo-1-pyrrolidinyl) ester DI(N-SUCCINIMIDYL) 3,3'-DITHIODIPROPIONATE MFCD00042045 3,3'-dithiodipropionic acid, bis(succinimido) ester SULFO-DSS dithiobis(succinimidyl propionate) 3,3'-Dithio(succinimidyl Propionate) (DISULFOSUCCINIMIDYL)SUBERATE EINECS 260-931-5 1,1'-{Disulfanediylbis[(1-oxopropane-3,1-diyl)oxy]}dipyrrolidine-2,5-dione 3,3′-Dithiodipropionic acid di 3,3'-Dithiodipropionic Acid Bis(N-succinimidyl Ester) 3,3'-Dithiodipropionic Acid Di(N-succinimidyl Ester)

Description	DSP Crosslinker is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog	Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Research Areas >> Inflammation/Immunology
Target	Cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References	[1]. Zorea J, et al. Probing antibody surface density and analyte antigen incubation time as dominant parameters influencing the antibody-antigen recognition events of a non-faradaic and diffusion-restricted electrochemical immunosensor. Anal Bioanal Chem. 2020 Mar;412(7):1709-1717.

Density	1.6±0.1 g/cm3
Boiling Point	560.1±60.0 °C at 760 mmHg
Melting Point	128-133 °C
Molecular Formula	C₁₄H₁₆N₂O₈S₂
Molecular Weight	404.415
Flash Point	292.6±32.9 °C
Exact Mass	404.034790
PSA	177.96000
LogP	-1.66
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.625
Storage condition	2-8°C
Water Solubility	chloroform: 50 mg/mL

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2930909090

Precursor 3
6066-82-6 1119-62-6 74124-79-1
DownStream 0

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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