120533-76-8
120533-76-8 structure
- Name: Diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate
- Chemical Name: diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate
- CAS Number: 120533-76-8
- Molecular Formula: C24H25NO4
- Molecular Weight: 391.46
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
- Create Date: 2017-06-29 20:01:24
- Modify Date: 2024-02-04 12:36:09
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BML-278 is a SIRT1 activator (EC150: 1 μM). BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in both the paternal and maternal pronucleus. BML-278 improves early embryonic development. BML-278 arrests the cell cycle at the G1/S phase, and reduces senescence in primary human mesenchymal cells. BML-278 reduces tubulin acetylation in U937 cells. BML-278 also increases mitochondrial density in murine C2C12 myoblasts[1][2].
| Name | diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate |
|---|---|
| Synonyms | .diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate |
| Description | BML-278 is a SIRT1 activator (EC150: 1 μM). BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in both the paternal and maternal pronucleus. BML-278 improves early embryonic development. BML-278 arrests the cell cycle at the G1/S phase, and reduces senescence in primary human mesenchymal cells. BML-278 reduces tubulin acetylation in U937 cells. BML-278 also increases mitochondrial density in murine C2C12 myoblasts[1][2]. |
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| Related Catalog | |
| Target |
SIRT1[1]. |
| References |
| Molecular Formula | C24H25NO4 |
|---|---|
| Molecular Weight | 391.46 |
| Exact Mass | 391.17800 |
| PSA | 55.84000 |
| LogP | 4.11790 |
| Precursor 0 | |
|---|---|
| DownStream 1 | |
