519055-63-1
519055-63-1 structure
- Name: Tasisulam sodium
- Chemical Name: sodium,(5-bromothiophen-2-yl)sulfonyl-(2,4-dichlorobenzoyl)azanide
- CAS Number: 519055-63-1
- Molecular Formula: C11H5BrCl2NNaO3S2
- Molecular Weight: 437.09200
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2017-07-01 14:44:00
- Modify Date: 2025-08-24 18:38:40
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Tasisulam sodium (LY 573636 sodium) is a small molecule antitumor agent that inhibits mitotic progression and induces vascular normalization. Tasisulam sodium induces apoptosis via the intrinsic pathway[1].
| Name | sodium,(5-bromothiophen-2-yl)sulfonyl-(2,4-dichlorobenzoyl)azanide |
|---|---|
| Synonyms |
Tasisulam sodium
Tasisulam sodium (USAN) |
| Description | Tasisulam sodium (LY 573636 sodium) is a small molecule antitumor agent that inhibits mitotic progression and induces vascular normalization. Tasisulam sodium induces apoptosis via the intrinsic pathway[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Tasisulam sodium (200 μM-200 nM; 48 hours) induces an antiproliferative response across a wide range of tumor histologies with EC50s is 10 μM and 25 μM for Calu-6 and A-375 cell lines, respectively[1]. Tasisulam sodium (25, 50 μM; 72 hours) induces a concentration-dependent increase in 4N DNA and G2-M accumulation[1]. Tasisulam sodium (200 μM-200 nM; 48 hours) induces apoptosis in a broad range of in vitro cancer cell models[1]. Cell Proliferation Assay[1] Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models Concentration: 200 μM-200 nM Incubation Time: 48 hours Result: Induced an antiproliferative response across a wide range of tumor histologies with EC50s is 10 μM and 25 μM, respectively. Cell Cycle Analysis[1] Cell Line: Calu-6 and A-375 cell lines Concentration: 25, 50 μM Incubation Time: 72 hours Result: Induced a concentration-dependent increase in 4N DNA and G2-M accumulation. Apoptosis Analysis[1] Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models Concentration: 200 μM-200 nM Incubation Time: 48 hours Result: Induced apoptosis in a broad range of in vitro cancer cell models. |
| References |
| Molecular Formula | C11H5BrCl2NNaO3S2 |
|---|---|
| Molecular Weight | 437.09200 |
| Exact Mass | 434.81700 |
| PSA | 106.18000 |
| LogP | 5.46420 |