Tasisulam sodium
Modify Date: 2024-01-10 21:41:34
Tasisulam sodium structure
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Common Name | Tasisulam sodium | ||
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| CAS Number | 519055-63-1 | Molecular Weight | 437.09200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H5BrCl2NNaO3S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Tasisulam sodiumTasisulam sodium (LY 573636 sodium) is a small molecule antitumor agent that inhibits mitotic progression and induces vascular normalization. Tasisulam sodium induces apoptosis via the intrinsic pathway[1]. |
| Name | sodium,(5-bromothiophen-2-yl)sulfonyl-(2,4-dichlorobenzoyl)azanide |
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| Synonym | More Synonyms |
| Description | Tasisulam sodium (LY 573636 sodium) is a small molecule antitumor agent that inhibits mitotic progression and induces vascular normalization. Tasisulam sodium induces apoptosis via the intrinsic pathway[1]. |
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| Related Catalog | |
| In Vitro | Tasisulam sodium (200 μM-200 nM; 48 hours) induces an antiproliferative response across a wide range of tumor histologies with EC50s is 10 μM and 25 μM for Calu-6 and A-375 cell lines, respectively[1]. Tasisulam sodium (25, 50 μM; 72 hours) induces a concentration-dependent increase in 4N DNA and G2-M accumulation[1]. Tasisulam sodium (200 μM-200 nM; 48 hours) induces apoptosis in a broad range of in vitro cancer cell models[1]. Cell Proliferation Assay[1] Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models Concentration: 200 μM-200 nM Incubation Time: 48 hours Result: Induced an antiproliferative response across a wide range of tumor histologies with EC50s is 10 μM and 25 μM, respectively. Cell Cycle Analysis[1] Cell Line: Calu-6 and A-375 cell lines Concentration: 25, 50 μM Incubation Time: 72 hours Result: Induced a concentration-dependent increase in 4N DNA and G2-M accumulation. Apoptosis Analysis[1] Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models Concentration: 200 μM-200 nM Incubation Time: 48 hours Result: Induced apoptosis in a broad range of in vitro cancer cell models. |
| References |
| Molecular Formula | C11H5BrCl2NNaO3S2 |
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| Molecular Weight | 437.09200 |
| Exact Mass | 434.81700 |
| PSA | 106.18000 |
| LogP | 5.46420 |
| Tasisulam sodium |
| Tasisulam sodium (USAN) |