- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Naftopidil dihydrochloride
- Price: ￥716.0/100mg ￥2866.0/1g ￥356.0/25mg ￥1146.0/250mg
- Purity: 97.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Naftopidil dihydrochloride
- Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
57149-08-3
57149-08-3 structure
- Name: Naftopidil dihydrochloride
- Chemical Name: 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol,dihydrochloride
- CAS Number: 57149-08-3
- Molecular Formula: C24H30Cl2N2O3
- Molecular Weight: 392.491
- Catalog: API Circulatory system medication Prevention and treatment of angina pectoris
- Create Date: 2018-07-31 15:53:06
- Modify Date: 2024-01-02 18:26:28
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Naftopidil dihydrochloride (KT-611 dihydrochloride) is a selective alpha1-adrenoceptor antagonist, with antiproliferative effects. Naftopidil dihydrochloride can be used for the research of prostate hyperplasia[1].
| Name | 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol,dihydrochloride |
|---|---|
| Synonyms |
Avishot
Naftopidil DiHCl KT-611 dihydrochloride Naftopidildihydrochloride RS-1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphthoxy)-2-propanol flivas dihydrochloride 1-(2-Methoxyphenyl)-4-[3-(naphth-1-yloxy)-2-hydroxypropyl]-piperazine 4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]-1-piperazineethanol S1387_Selleck Flivas 1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphthyloxy)-2-propanol 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalen-1-yloxy)propan-2-ol 1-Piperazineethanol, 4-(2-methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]- Naftopidil 1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-(1-naphthyloxy)propan-2-ol |
| Description | Naftopidil dihydrochloride (KT-611 dihydrochloride) is a selective alpha1-adrenoceptor antagonist, with antiproliferative effects. Naftopidil dihydrochloride can be used for the research of prostate hyperplasia[1]. |
|---|---|
| Related Catalog | |
| Target |
α1-adrenoceptor[1] |
| In Vitro | Naftopidil dihydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma[1]. Naftopidil dihydrochloride (10 μM for PCa cells; 0.1-10 Μm for PrSC) shows growth inhibitory effects on PrSC and PCa cells[1]. Naftopidil dihydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC[1]. Cell Proliferation Assay[1] Cell Line: PCa cells, PrSC Concentration: 10 μM (PCa cells); 0.1 μM, 1 μM, 10 μM (PrSC) Incubation Time: 3 days Result: Exhibited growth inhibitory effects on PCa cells, PrSC in dose-dependent manners. Western Blot Analysis[1] Cell Line: PCa cells, PrSC Concentration: 50 μM (E9 cells), 25 μM (PrSC) Incubation Time: 48 hours Result: Increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC. |
| In Vivo | Naftopidil dihydrochloride (10 mg/kg; p.o; daily, for 28 days) decreases microvessel density (MVD) in E9 + PrSC tumors mice model[1]. Male athymic mice(7-8 weeks), with E9 + PrSC xenograft [1] Animal Model: Male athymic mice(7-8 weeks), with E9 + PrSC xenograft [1] Dosage: 10 mg/kg Administration: Oral administration, daily, for 28 days Result: Decrease tumor weights. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 602.8±55.0 °C at 760 mmHg |
| Melting Point | 212-213° |
| Molecular Formula | C24H30Cl2N2O3 |
| Molecular Weight | 392.491 |
| Flash Point | 318.3±31.5 °C |
| Exact Mass | 392.209991 |
| PSA | 45.17000 |
| LogP | 4.81 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.619 |
| Storage condition | -20℃ |
| Water Solubility | methanol: >10 mg/mL |
| WGK Germany | 3 |
|---|---|
| RTECS | TL9336500 |