Naftopidil dihydrochloride

Modify Date: 2024-01-02 18:26:28

Naftopidil dihydrochloride structure	Common Name	Naftopidil dihydrochloride
	CAS Number	57149-08-3	Molecular Weight	392.491
	Density	1.2±0.1 g/cm3	Boiling Point	602.8±55.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₃₀Cl₂N₂O₃	Melting Point	212-213°
	MSDS	N/A	Flash Point	318.3±31.5 °C

Use of Naftopidil dihydrochloride

Naftopidil dihydrochloride (KT-611 dihydrochloride) is a selective alpha1-adrenoceptor antagonist, with antiproliferative effects. Naftopidil dihydrochloride can be used for the research of prostate hyperplasia[1].

Name	1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol,dihydrochloride
Synonym	More Synonyms

Description	Naftopidil dihydrochloride (KT-611 dihydrochloride) is a selective alpha1-adrenoceptor antagonist, with antiproliferative effects. Naftopidil dihydrochloride can be used for the research of prostate hyperplasia[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	α1-adrenoceptor[1]
In Vitro	Naftopidil dihydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma[1]. Naftopidil dihydrochloride (10 μM for PCa cells; 0.1-10 Μm for PrSC) shows growth inhibitory effects on PrSC and PCa cells[1]. Naftopidil dihydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC[1]. Cell Proliferation Assay[1] Cell Line: PCa cells, PrSC Concentration: 10 μM (PCa cells); 0.1 μM, 1 μM, 10 μM (PrSC) Incubation Time: 3 days Result: Exhibited growth inhibitory effects on PCa cells, PrSC in dose-dependent manners. Western Blot Analysis[1] Cell Line: PCa cells, PrSC Concentration: 50 μM (E9 cells), 25 μM (PrSC) Incubation Time: 48 hours Result: Increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.
In Vivo	Naftopidil dihydrochloride (10 mg/kg; p.o; daily, for 28 days) decreases microvessel density (MVD) in E9 + PrSC tumors mice model[1]. Male athymic mice(7-8 weeks), with E9 + PrSC xenograft [1] Animal Model: Male athymic mice(7-8 weeks), with E9 + PrSC xenograft [1] Dosage: 10 mg/kg Administration: Oral administration, daily, for 28 days Result: Decrease tumor weights.
References	[1]. Yasuhide Hori, et al. Naftopidil, a selective {alpha}1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Cancer Prev Res (Phila). 2011 Jan;4(1):87-96.

Density	1.2±0.1 g/cm3
Boiling Point	602.8±55.0 °C at 760 mmHg
Melting Point	212-213°
Molecular Formula	C₂₄H₃₀Cl₂N₂O₃
Molecular Weight	392.491
Flash Point	318.3±31.5 °C
Exact Mass	392.209991
PSA	45.17000
LogP	4.81
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.619
Storage condition	-20℃
Water Solubility	methanol: >10 mg/mL

WGK Germany	3
RTECS	TL9336500

Avishot

Naftopidil DiHCl

KT-611 dihydrochloride

Naftopidildihydrochloride

RS-1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphthoxy)-2-propanol

flivas dihydrochloride

1-(2-Methoxyphenyl)-4-[3-(naphth-1-yloxy)-2-hydroxypropyl]-piperazine

4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]-1-piperazineethanol

S1387_Selleck

Flivas

1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphthyloxy)-2-propanol

1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalen-1-yloxy)propan-2-ol

1-Piperazineethanol, 4-(2-methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-

Naftopidil

1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-(1-naphthyloxy)propan-2-ol

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Naftopidil dihydrochloride
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Naftopidil dihydrochloride
Price: ￥716.0/100mg ￥2866.0/1g ￥356.0/25mg ￥1146.0/250mg
Purity: 97.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Naftopidil dihydrochloride
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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