1354638-93-9
1354638-93-9 structure
- Name: Araliadiol
- Chemical Name: (3R,8S,Z)-pentadeca-1,9-dien-4,6-diyne-3,8-diol
- CAS Number: 1354638-93-9
- Molecular Formula: C15H20O2
- Molecular Weight: 232.318
- Catalog: Research Areas Cancer
- Create Date: 2017-04-13 18:54:35
- Modify Date: 2024-01-02 08:29:21
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Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cells growth with an IC50 value of 6.41 µg/mL[1].
| Name | (3R,8S,Z)-pentadeca-1,9-dien-4,6-diyne-3,8-diol |
|---|---|
| Synonyms |
1,9-Pentadecadiene-4,6-diyne-3,8-diol, (3R,8S,9Z)-
(3R,8S,9Z)-1,9-Pentadecadiene-4,6-diyne-3,8-diol |
| Description | Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cells growth with an IC50 value of 6.41 µg/mL[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 6.41 µg/mL (MCF-7 cells growth)[1] |
| In Vitro | Araliadiol (20-80 µM; 0-48 hours; MCF-7 cells) treatment inhibits cell cycle progression of MCF-7 at the G1-S transition[1]. Araliadiol (20-80 µM; 0-48 hours; MCF-7 cells) treatment inhibits phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells, accompanies by a decrease in the levels of cyclin D3 and cdk4 and an increase in the expression of p21 (WAF-1/Cip1)[1]. Cell Cycle Analysis[1] Cell Line: MCF-7 cells Concentration: 20 µM, 40 µM, and 80 µM Incubation Time: 0 hour, 6 hours, 12 hours, 18 hours, 24 hours, and 48 hours Result: The proportion of cells in the G1 phase of the cell cycle increased in a dose-dependent manner (from 54.7 % to 72.0 %). Western Blot Analysis[1] Cell Line: MCF-7 cells Concentration: 20 µM, 40 µM, and 80 µM Incubation Time: 48 hours Result: Phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells was inhibited, accompanied by a decrease in the levels of cyclin D3 and cyclin-dependent kinase 4 (cdk4) and an increase in the expression of p21 (WAF-1/Cip1). |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 381.2±42.0 °C at 760 mmHg |
| Molecular Formula | C15H20O2 |
| Molecular Weight | 232.318 |
| Flash Point | 176.1±22.5 °C |
| Exact Mass | 232.146332 |
| PSA | 40.46000 |
| LogP | 5.26 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.531 |
| Hazard Codes | Xi |
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