Araliadiol

Modify Date: 2024-01-02 08:29:21

Araliadiol Structure
Araliadiol structure
Common Name Araliadiol
CAS Number 1354638-93-9 Molecular Weight 232.318
Density 1.0±0.1 g/cm3 Boiling Point 381.2±42.0 °C at 760 mmHg
Molecular Formula C15H20O2 Melting Point N/A
MSDS N/A Flash Point 176.1±22.5 °C

 Use of Araliadiol


Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cells growth with an IC50 value of 6.41 µg/mL[1].

 Names

Name (3R,8S,Z)-pentadeca-1,9-dien-4,6-diyne-3,8-diol
Synonym More Synonyms

 Araliadiol Biological Activity

Description Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cells growth with an IC50 value of 6.41 µg/mL[1].
Related Catalog
Target

IC50: 6.41 µg/mL (MCF-7 cells growth)[1]

In Vitro Araliadiol (20-80 µM; 0-48 hours; MCF-7 cells) treatment inhibits cell cycle progression of MCF-7 at the G1-S transition[1]. Araliadiol (20-80 µM; 0-48 hours; MCF-7 cells) treatment inhibits phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells, accompanies by a decrease in the levels of cyclin D3 and cdk4 and an increase in the expression of p21 (WAF-1/Cip1)[1]. Cell Cycle Analysis[1] Cell Line: MCF-7 cells Concentration: 20 µM, 40 µM, and 80 µM Incubation Time: 0 hour, 6 hours, 12 hours, 18 hours, 24 hours, and 48 hours Result: The proportion of cells in the G1 phase of the cell cycle increased in a dose-dependent manner (from 54.7 % to 72.0 %). Western Blot Analysis[1] Cell Line: MCF-7 cells Concentration: 20 µM, 40 µM, and 80 µM Incubation Time: 48 hours Result: Phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells was inhibited, accompanied by a decrease in the levels of cyclin D3 and cyclin-dependent kinase 4 (cdk4) and an increase in the expression of p21 (WAF-1/Cip1).
References

[1]. Cheng WL, et al. Inhibitory effect of human breast cancer cell proliferation via p21-mediated G1 cell cycle arrest by araliadiol isolated from Aralia cordata Thunb. Planta Med. 2011 Jan;77(2):164-8.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 381.2±42.0 °C at 760 mmHg
Molecular Formula C15H20O2
Molecular Weight 232.318
Flash Point 176.1±22.5 °C
Exact Mass 232.146332
PSA 40.46000
LogP 5.26
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.531

 Safety Information

Hazard Codes Xi

 Synonyms

1,9-Pentadecadiene-4,6-diyne-3,8-diol, (3R,8S,9Z)-
(3R,8S,9Z)-1,9-Pentadecadiene-4,6-diyne-3,8-diol