81093-43-8

81093-43-8 structure

Name: 3α-Hydroxy pravastatin sodium
Chemical Name: sodium,(3R,5R)-7-[(1S,2R,3S,8S,8aR)-3-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,3,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
CAS Number: 81093-43-8
Molecular Formula: C₂₃H₃₅NaO₇
Molecular Weight: 446.51000
Catalog: Signaling Pathways Metabolic Enzyme/Protease HMG-CoA Reductase (HMGCR)
Create Date: 2016-06-29 09:28:59
Modify Date: 2024-01-04 01:04:09
3α-Hydroxy pravastatin sodium is the major metabolite of Pravastatin. Pravastatin is a competitive HMG-CoA reductase inhibitor[1][2].

Name	sodium,(3R,5R)-7-[(1S,2R,3S,8S,8aR)-3-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,3,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
Synonyms	3alpha-Hydroxy Pravastatin Sodium Salt 3\|A-Hydroxy Pravastatin Sodium Salt UNII-TC279YC5KM Pravastatin related compound A

Description	3α-Hydroxy pravastatin sodium is the major metabolite of Pravastatin. Pravastatin is a competitive HMG-CoA reductase inhibitor[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)
References	[1]. Zhang X, Vernikovskaya DI, Wang X, et al. Quantitative determination of pravastatin and its metabolite 3α-hydroxy pravastatin in plasma and urine of pregnant patients by LC-MS/MS. Biomed Chromatogr. 2016;30(4):548‐554. [2]. Shiomi M, et al. Pravastatin sodium, a competitive inhibitor of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase, decreases the cholesterol content of newly secreted very-low-density lipoprotein in Watanabe heritable hyperlipidemic rabbits. Metabolism. 1994;43(5):559‐564.

Hazard Codes	Xn
RIDADR	NONH for all modes of transport