1333382-30-1

1333382-30-1 structure

Name: CX-5011
Chemical Name: sodium,5-(3-ethynylanilino)pyrimido[4,5-c]quinoline-8-carboxylate
CAS Number: 1333382-30-1
Molecular Formula: C₂₀H₁₁N₄NaO₂
Molecular Weight: 362.31700
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-12-12 04:54:42
Modify Date: 2024-09-17 09:03:17
CX-5011 is a CK2 inhibitor. CX-5011 also induces Rac1 activation. CX-5011 induces apoptosis and induces cancer cell death[1][2].

Name	sodium,5-(3-ethynylanilino)pyrimido[4,5-c]quinoline-8-carboxylate
Synonyms	UNII-2F5JG09KS6 Pyrimido(4,5-C)quinoline-8-carboxylic acid,5-((3-ethynylphenyl)amino)-,sodium salt (1:1) CX-5011

Description	CX-5011 is a CK2 inhibitor. CX-5011 also induces Rac1 activation. CX-5011 induces apoptosis and induces cancer cell death[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase
References	[1]. D'Amore C, et al. "Janus" efficacy of CX-5011: CK2 inhibition and methuosis induction by independent mechanisms. Biochim Biophys Acta Mol Cell Res. 2020 Nov;1867(11):118807. [2]. Salizzato V, et al. Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies. Oncotarget. 2016 Apr 5;7(14):18204-18.