30271-38-6
30271-38-6 structure
- Name: 24-Hydroxycholesterol
- Chemical Name: cholest-5-ene-3β,24ξ-diol
- CAS Number: 30271-38-6
- Molecular Formula: C27H46O2
- Molecular Weight: 402.65300
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
- Create Date: 2017-06-19 18:28:09
- Modify Date: 2024-01-02 22:26:32
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24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.
| Name | cholest-5-ene-3β,24ξ-diol |
|---|---|
| Synonyms | 24-Hydroxycholesterol |
| Description | 24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR. |
|---|---|
| Related Catalog | |
| In Vitro | 24S-hydroxycholesterol oxysterol-generating enzyme Cyp46a1 is overexpressed during the angiogenic switch in rat insulin promoter 1-T-antigen 2 (RIP1-Tag2) pNET formation[1]. |
| In Vivo | Hypoxia inducible factor-1a (HIF-1α) controls the overexpression of the enzyme Cyp46a1, which generates the oxysterol 24-hydroxycholesterol in a pancreatic neuroendocrine tumor (pNET) model commonly used to study neoangiogenesis. The activation of the HIF-1α-24S-HC axis ultimately leads to the induction of the angiogenic switch through the positioning of proangiogenic neutrophils in proximity to Cyp46a1+ islets[1]. 24-hydroxycholesterol levels are increased at 2-4 months in the untreated 5XFAD mouse brain and then became similar to those in the B6SJL mouse brain[2]. |
| References |
| Molecular Formula | C27H46O2 |
|---|---|
| Molecular Weight | 402.65300 |
| Exact Mass | 402.35000 |
| PSA | 40.46000 |
| LogP | 6.35950 |
| Storage condition | 2-8℃ |