4237-93-8

4237-93-8 structure

Name: ACTH (11-24)
Chemical Name: Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro
CAS Number: 4237-93-8
Molecular Formula: C₇₇H₁₃₄N₂₄O₁₆
Molecular Weight: 1652.04
Catalog: Peptides
Create Date: 2016-10-14 02:55:31
Modify Date: 2024-01-07 11:52:03
ACTH (11-24) is a fragment of adrenocorticotrophin, acts as an antagonist of adrenocorticotropic hormone (ACTH) receptor, and induces cortisol release.

Name	Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro
Synonyms	acth (11-24)

Description	ACTH (11-24) is a fragment of adrenocorticotrophin, acts as an antagonist of adrenocorticotropic hormone (ACTH) receptor, and induces cortisol release.
Related Catalog	Signaling Pathways >> Others >> Others Peptides Research Areas >> Inflammation/Immunology
Target	Adrenocorticotropic hormone receptor[1]
In Vitro	ACTH (11-24) acts as an antagonist of adrenocorticotropic hormone receptor[1]. ACTH (11-24) induces cortisol secretion submaximally in freshly dispersed or cultured beef adrenal cortical cells. The maximal cortisol release by ACTH (11-24) is enhanced by forskolin but inhibited by calcium channel blockers[2].
In Vivo	ACTH (11-24) blocks electroacupuncture (EA) anti-edema but not EA anti-hyperalgesia in rats[1].
References	[1]. Li ZG, et al. Adrenocorticotropin(1-10) and -(11-24) promote adrenal steroidogenesis by different mechanisms. Endocrinology. 1989 Aug;125(2):592-6. [2]. Li A, et al. Electroacupuncture activates corticotrophin-releasing hormone-containing neurons in the paraventricular nucleus of the hypothalammus to alleviate edema in a rat model of inflammation. BMC Complement Altern Med. 2008 May 12;8:20.