1375603-36-3
1375603-36-3 structure
- Name: VT-464 (racemate)
- Chemical Name: 1-(6,7-bis(difluoromethoxy)naphthalen-2-yl)-2-methyl-1-(1H-1,2,3-triazol-4-yl)propan-1-ol
- CAS Number: 1375603-36-3
- Molecular Formula: C18H17F4N3O3
- Molecular Weight: 399.33900
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
- Create Date: 2017-03-08 14:45:08
- Modify Date: 2025-08-21 17:22:23
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Seviteronel (VT-464) racemate is the racemate form of Seviteronel (VT-464), which is a potent CYP17 lyase inhibitor(h-Lyase IC50=nM)inhibition.
| Name | 1-(6,7-bis(difluoromethoxy)naphthalen-2-yl)-2-methyl-1-(1H-1,2,3-triazol-4-yl)propan-1-ol |
|---|---|
| Synonyms |
VT-464 racemate
VT-464 (racemate) |
| Description | Seviteronel (VT-464) racemate is the racemate form of Seviteronel (VT-464), which is a potent CYP17 lyase inhibitor(h-Lyase IC50=nM)inhibition. |
|---|---|
| Related Catalog | |
| Target |
IC50: 69 nM(VT-464, h-CYP17 Lyase)[1]. |
| In Vitro | Seviteronel (VT-464), a non-steroidal small molecule inhibits androgen production without mineralocorticoid excess or cortisol depletion by selective inhibition of CYP17 17,20-lyase. We determined the impact of Seviteronel on tumor growth of a mCRPC xenograft, MDA-PCa-133, in vivo, and on androgen signaling in C4-2B prostate cancer cells in vitro [2]. |
| In Vivo | The MDA-PCa-133 xenograft is derived from a clinical CRPC bone metastasis. Subcutaneous MDA-PCa-133 tumor expresses PSA, full-length androgen receptor (AR) and AR-V7 isoform. We determined the effect of Seviteronel (VT-464) and AA on MDA-PCa-133 growing in tumor-bearing castrated male mice: randomization into three groups; oral treatment with vehicle only, Seviteronel (VT-464), (100 mg/kg bid), or AA (100 mg/kg bid) for 25 days. Both Seviteronel (VT-464) and AA reduced tumor volume (>two fold compared to vehicle; p<0.05). These results indicate that selective Seviteronel (VT-464) CYP17 lyase inhibition is as effective as AA CYP17 inhibition in this model [2]. |
| References |
| Molecular Formula | C18H17F4N3O3 |
|---|---|
| Molecular Weight | 399.33900 |
| Exact Mass | 399.12100 |
| PSA | 80.26000 |
| LogP | 4.05260 |