Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pyridoxamine dihydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Pyridoxamine dihydrochloride
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

524-36-7

524-36-7 structure

Name: Pyridoxamine dihydrochloride
Chemical Name: Pyridoxamine dihydrochloride
CAS Number: 524-36-7
Molecular Formula: C₈H₁₄Cl₂N₂O₂
Molecular Weight: 241.115
Catalog: API Vitamins and minerals Vitamin B drugs
Create Date: 2018-02-23 08:00:00
Modify Date: 2026-07-02 10:39:05

Name	Pyridoxamine dihydrochloride
Synonyms	4-AMINOMETHYL-5-HYDROXY-6-METHYL-3-PYRIDINEMETHANOL DIHYDROCHLORIDE 4-(aminomethyl)-5-(hydroxymethyl)-2-methyl-3-pyridinol Pazopanib Impurity 98 2-methylpyridin-3-ol dihydrochloride Pyridoxamine Dihydrochloride PYRIDOXAMINE 2HCL 3-Pyridinemethanol, 4-(aminomethyl)-5-hydroxy-6-methyl-,dihydrochloride PYRIDOXAMINE DIHYDROCHLORIDE, CELL*CULTU RE TESTED Pyridoxamine dihydrochlorideQ: What is Pyridoxamine dihydrochloride Q: What is the CAS Number of Pyridoxamine dihydrochloride Q: What is the storage condition of Pyridoxamine dihydrochloride Pyridoxamine, dihydrochloride Pyridoxamine, Dihydrochloride - - Calbiochem PyridoxaMin Dihydrochloride Pyridoxamine dichlorohydrate 2-Methyl-3-hydroxy-4-aMinoMethyl-5-hydroxMethylpyridine Dihydrochloride pyridoxylamine dihydrochloride Dyridoxamine hydrochloride vitamin B6dihydrochloride 2-Methyl-3-hydroxy-4-aminomethyl-5-hydroxymethylpyridine dihydrochloride 287091_ALDRICH 3-Pyridinemethanol, 4-(aminomethyl)-5-hydroxy-6-methyl-, hydrochloride (1:2) Pyridoxamine dihydrochloride (Vitamin B6) 3-PyridineMethanol,4-(aMinoMethyl)-5-hydroxy-6-Methyl-, hydrochloride (1:2) 4-(AMINOMETHYL)-5-HYDROXY-6-METHYL-3-PYRIDENEMETHANOL DIHYDROCHLORIDE yridoxamin Dihydrochloride 3-Pyridinemethanol, 4-(aminomethyl)-5-hydroxy-6-methyl-, dihydrochloride (9CI) Pyridoxamine Dihydrochloride Monohydrate Pyridoxamine dihydrochloride,4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol dihydrochloride 4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol dihydrochloride PyridoxaMinetwohydrochloride 4-(aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanodihydrochloride dihydrochL Pyridoxamine dihydrochloride //BP 4-(aminomethyl)-5-(hydroxymethyl)-2 pyridoxaminedihydrochloride Pyridoxamine dihydro Pyridoxamine dihydrochloride, (B6 Derivative) 4-(Aminomethyl)-5-Hydroxy-6-Methyl-3-Pyridenemetha 4-(Aminomethyl)-5-(hydroxymethyl)-2-methyl-3-pyridinol dihydrochloride Pyridoxamine·2hydrochloride 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol(SALTDATA: 2HCl) 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol dihydrochloride Pyridomide hydrochloride PYRIDOXAMINE Pyridoxamine Dihydrochloride Standd pyridoxal amine dihydrochloride Pyridoxamine-[2H3] dihydrochloride 4-(Aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol dihydrochloride P9380_SIGMA 2-methyl-3-hydroxy-4-aminomethyl-5-hydroxymethylpyridenedihydrochloride 3-Pyridinemethanol, 4- (aminomethyl)-5-hydroxy-6-methyl-, dihydrochloride PYRIDOXEMINE, DIHYDROCHLORIDE PyridoxaMine 2HC1 Pyridoxamine, dihydrochloride (8CI) PyridoxaMine dihydrochloride SynonyMs 4-(AMinoMethyl)-5-hydroxy-6-Methyl-3-pyridineMethanol dihydrochloride PYRIDOXAMINE HCL P9158_SIGMA EINECS 208-357-6 4-(aminomethyl)-2-methyl-5-methylol-pyridin-3-ol dihydrochloride 4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol Dihydrochloride, 2-Methyl-3-hydroxy-4-aminomethyl-5-hydroxmethylpyridine Dihydrochloride 4-(aminomethyl)-5-(hydroxymethyl)-2-methyl-3-pyridinol dihydrochloride PyridoxylaMine Dihydrochloride Pyridoxamine Dihydrochloride in 0.1mol/LHCl (as free base) pyridoxamine bishydrochloride Pyridoxamine hydrochloride Pyridoxylamine dihydrochloride, 10 mM in DMSO )-5-(hydroxymethyL Pyridoxamine DiHCl PYRIDOXAMINE DIHYDROCHLORIDE MFCD00012808 2-Methyl-3-hydroxy-4-aminomethyl 82885_FLUKA

Density	1.282g/cm3
Boiling Point	460.1ºC at 760 mmHg
Melting Point	224-226 °C (dec.)(lit.)
Molecular Formula	C₈H₁₄Cl₂N₂O₂
Molecular Weight	241.115
Flash Point	232.1ºC
Exact Mass	240.043228
PSA	79.37000
LogP	2.35090
Storage condition	−20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV1230000

CHEMICAL NAME :: Pyridoxamine dihydrochloride

CAS REGISTRY NUMBER :: 524-36-7

LAST UPDATED :: 199504

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C8-H12-N2-O2.2Cl-H

MOLECULAR WEIGHT :: 241.14

WISWESSER LINE NOTATION :: T6NJ B1 CQ D1Z E1Q &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4720 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5100 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2950 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 590 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 540 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 795 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4950 No. of Facilities: 6 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 44 (estimated) No. of Female Employees: 32 (estimated)

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	UV1230000
HS Code	2933399090

408335-89-7

~83%

524-36-7

Literature: KANDULA, Mahesh Patent: WO2013/167991 A1, 2013 ; Location in patent: Paragraph 00103; 00104 ;

863030-57-3

524-36-7

Literature: BIOSTRATUM, INC. Patent: WO2005/77902 A2, 2005 ; Location in patent: Page/Page column 40-42 ;

20905-66-2

~94%

524-36-7

Literature: Balyakina, M. V.; Yakovleva, N. L.; Gunar, V. I. Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 6 p. 407 - 409 Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 6 p. 79 - 81

58-56-0

524-36-7

Literature: Balyakina, M. V.; Yakovleva, N. L.; Gunar, V. I. Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 6 p. 407 - 409 Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 6 p. 79 - 81

Precursor 4
408335-89-7 863030-57-3 20905-66-2 58-56-0
DownStream 4
529-96-4 58-56-0 54-47-7 97994-72-4

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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