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58-56-0

58-56-0 structure
58-56-0 structure
  • Name: Pyridoxine hydrochloride
  • Chemical Name: pyridoxine hydrochloride
  • CAS Number: 58-56-0
  • Molecular Formula: C8H12ClNO3
  • Molecular Weight: 205.639
  • Catalog: Food additive Nutrition supplements Vitamins
  • Create Date: 2018-08-26 19:29:14
  • Modify Date: 2026-07-01 11:09:46
  • Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
Name pyridoxine hydrochloride
Synonyms PYRIDOXINE HYDROCHLORIDE
bonasanit
vitamin B6 hydrochloride
Hexobion
Pyridoxine HCl (Vitamin B6) solution
5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride
Vitamin B6 Hcl (Pyridoxine Hcl)
(Synonyms: Pyridoxol (hydrochloride)
Pyridoxine hydrochloride, extra
Pyridoxin hydr
(SYNONYMS: PYRIDOXOL (HYDROCHLORIDE); VITAMIN B6 (HYDROCHLORIDE))
hexabionehydrochloride
hexermin
adermine hydrochloride
Adermin hydrochloride
3-hydroxy-4,5-dimethylol-alpha-picolinehydrochloride
Pyridoxine HCl
Pyridoxinium chloride
Bonasanit
PyridoxineHydrochlorideForBiochemistry-(VitaminB6Hydrochloride)
Adermine hydrochloride Pyridoxine hydrochloride PN HCl
PYRIDOXINE HCL
Pyridoxine hydrogen chloride
campoviton6
MFCD08064207
Pyridoxine hydrochloride Vetec(TM) ade
Pyridoxine hydrochloride (Synonyms: Pyridoxol (hydrochloride)
PyridoxineHydrochlorideForBiochemistry
Hexabetalin
VitaminB6.HCl/Pyridoxine.HClHCl
pyridoxine monohydrochloride
EINECS 200-386-2
2-Methyl-3-oxy-4,5-di(oxymethyl)-pyridine hydrochloride
(5-hydroxy-6-methylpyridine-3,4-diyl)dimethanol hydrochloride
becilan
3-Hydroxy-4,5-dimethylol-α-picoline hydrochloride
Adermine hydrochloride, PN HCl, Pyridoxine hydrochloride, Pyridoxol hydrochloride, VitaminB6 hydrochloride
pyridoxiniumchloride
PYRIDOXINEHYDROCHLORIDE,FCC
Adermine hydrochloride, PN HCl, Pyridoxol hydrochloride, VitaminB6 hydrochloride
4,5-Bis(hydroxymethyl)-2-methyl-3-pyridinol hydrochloride (1:1)
Adermine hydrochloridel
PyridoxineHydrochlorideB.P.,U.S.P
hexobion
3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride (1:1)
PYRIDOXINEHCL(VITAMINB6)
PYRIDOXINE HYDROCHLORIDE, BIOREAGENT
Pyridox
3-Hydroxy-4,5-dimethylol-a-picoline hydrochloride
Hexavibex
aderoxin
pyridoxine hydrochloride (b6)
Pyridoxine HCL(Vitamin B6) /BP
pyridoxinechloride
aderoxine
2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine hydrochloride
pyridoxinemonohydrochloride
Pyridoxine, hydrochloride
Pyridoxine HC1
hexavibex
pyridoxol hydrochloride
hexa-betalin(r)
Benadon
Pyridoxine Hydrochloride, Animal-Free
4,5-Di(hydroxymethyl)-2-methylpyridin-3-olhydrochloride
pyridox
paxadon
Pridoxinehydrochloride
T6NJ B1 CQ D1Q E1Q &&HCl
pyridipca
Vitamin B6 hydrochloride
5-Hydroxy-6-methyl-3,4-pyridinedimethanol
4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride (1:1)
Pyridoxol HCl
hexabetalin
Pyridoxyl hydrochloride
Pyridoxol hydrochloride
Pyridoxine hydrochloride, (HPLC)
benadon
pyridoxinehydrogenchloride
5-hydroxy--6-methyl-3,4-pyridine dimethanol hydrochloride
Description Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
Related Catalog
Target

Nrf2[1]

In Vitro Pyridoxine exerts a protective potential against AD, attenuates ROS levels, decreases the expressions of cytoplasmic Nrf2, and upregulates whole-cell HO-1 expression[1].
References

[1]. Li C, et al. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway. Cell Mol Biol (Noisy-le-grand). 2018 Jul 30;64(10):119-124.
Boiling Point 491.9ºC at 760 mmHg
Melting Point 214-215 °C(lit.)
Molecular Formula C8H12ClNO3
Molecular Weight 205.639
Flash Point 251.3ºC
Exact Mass 205.050568
PSA 73.58000
LogP 0.88220
Storage condition 2-8°C
Stability Stable. Protect from air and light.
Water Solubility 0.1 g/mL (20 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV1350000
CHEMICAL NAME :
Pyridoxol, hydrochloride
CAS REGISTRY NUMBER :
58-56-0
LAST UPDATED :
199712
DATA ITEMS CITED :
24
MOLECULAR FORMULA :
C8-H11-N-O3.Cl-H
MOLECULAR WEIGHT :
205.66
WISWESSER LINE NOTATION :
T6NJ B1 CQ D1Q E1Q &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
530 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2450 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
660 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
560 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
464 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Bird - pigeon
DOSE/DURATION :
145 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
21400 mg/kg/15W-I
TOXIC EFFECTS :
Spinal Cord - demyelination Behavioral - changes in motor activity (specific assay) Behavioral - ataxia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2 mg/kg
SEX/DURATION :
female 38 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - postpartum
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
2 mg/kg
SEX/DURATION :
female 38 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - postpartum
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
8040 ug/kg
SEX/DURATION :
female 14 week(s) pre-mating - 12 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - biochemical and metabolic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
4 gm/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
15 gm/kg
SEX/DURATION :
male 2 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
7500 mg/kg
SEX/DURATION :
male 6 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
15 gm/kg
SEX/DURATION :
male 6 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
2 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,175,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3950 No. of Facilities: 1955 (estimated) No. of Industries: 8 No. of Occupations: 39 No. of Employees: 57249 (estimated) No. of Female Employees: 35753 (estimated)
Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger
Hazard Statements H225-H301 + H311 + H331-H370
Precautionary Statements P210-P260-P280-P301 + P310-P311
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS UV1350000
HS Code 2936250000
HS Code 2936250000
Summary HS: 2936250000. (5-hydroxy-6-methylpyridine-3,4-diyl)dimethanol. VAT:17.0%. tax rebate rate:13.0%. supervision conditions:ab(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tarrif:4.0%. general tariff:20.0%
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