1020399-49-8

1020399-49-8 structure

Name: CARM1-IN-1
Chemical Name: 3,5-bis(3-bromo-4-hydroxybenzylidene)-1-benzylpiperidin-4-one
CAS Number: 1020399-49-8
Molecular Formula: C₂₆H₂₁Br₂NO₃
Molecular Weight: 555.25800
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2017-06-21 11:48:18
Modify Date: 2024-01-10 05:35:41
CARM1-IN-1 is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM). IC50 value: 8.6 uM [1]Target: CRAM1 inhibitorin vitro: CARM1-IN-1(Cmp 7g) displayed high and selective CARM1 inhibition, with lower or no activity against a panel of different PRMTs or HKMTs. In human LNCaP cells, 7g showed a significant dose-dependent reduction of the PSA promoter activity.

Name	3,5-bis(3-bromo-4-hydroxybenzylidene)-1-benzylpiperidin-4-one
Synonyms	CARM1-IN-1

Description	CARM1-IN-1 is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM). IC50 value: 8.6 uM [1]Target: CRAM1 inhibitorin vitro: CARM1-IN-1(Cmp 7g) displayed high and selective CARM1 inhibition, with lower or no activity against a panel of different PRMTs or HKMTs. In human LNCaP cells, 7g showed a significant dose-dependent reduction of the PSA promoter activity.
Related Catalog	Signaling Pathways >> Epigenetics >> Histone Methyltransferase Research Areas >> Cancer
References	[1]. Cheng D, et al. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14;54(13):4928-32.