CARM1-IN-1
Modify Date: 2024-01-10 05:35:41
CARM1-IN-1 structure
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Common Name | CARM1-IN-1 | ||
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| CAS Number | 1020399-49-8 | Molecular Weight | 555.25800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H21Br2NO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CARM1-IN-1CARM1-IN-1 is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM). IC50 value: 8.6 uM [1]Target: CRAM1 inhibitorin vitro: CARM1-IN-1(Cmp 7g) displayed high and selective CARM1 inhibition, with lower or no activity against a panel of different PRMTs or HKMTs. In human LNCaP cells, 7g showed a significant dose-dependent reduction of the PSA promoter activity. |
| Name | 3,5-bis(3-bromo-4-hydroxybenzylidene)-1-benzylpiperidin-4-one |
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| Synonym | More Synonyms |
| Description | CARM1-IN-1 is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM). IC50 value: 8.6 uM [1]Target: CRAM1 inhibitorin vitro: CARM1-IN-1(Cmp 7g) displayed high and selective CARM1 inhibition, with lower or no activity against a panel of different PRMTs or HKMTs. In human LNCaP cells, 7g showed a significant dose-dependent reduction of the PSA promoter activity. |
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| Related Catalog | |
| References |
| Molecular Formula | C26H21Br2NO3 |
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| Molecular Weight | 555.25800 |
| Exact Mass | 552.98900 |
| PSA | 60.77000 |
| LogP | 6.11260 |
| Storage condition | 2-8℃ |
| CARM1-IN-1 |