Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Yellow pyoctanine
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Purity: 98.0%
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492-80-8

492-80-8 structure

Name: Yellow pyoctanine
Chemical Name: auramine O free base
CAS Number: 492-80-8
Molecular Formula: C₁₇H₂₁N₃
Molecular Weight: 267.36900
Catalog: analytical chemistry Standard Cosmetic standard
Create Date: 2018-09-03 13:35:31
Modify Date: 2026-07-10 20:11:56

Name	auramine O free base
Synonyms	C.I.Solvent Yellow 34:C.I.41000:1 CISOLVENTYELLOW [4-[4-(dimethylamino)benzimidoyl]phenyl]-dimethyl-amine 4, 4 -Cbonimdoylbis[N,N-dimethylaniline] AURAMINE(-ADE) Cbonoimidoylbis(N,N-dimethylbenzenamine) Baso Yellow Blauramine C.I. 41000B C.I. Basic Yellow 2, Free Base Auramine OAF 4,4'-cbonimidoylbis[N,N-dimethylaniline] C.I.41000:1 4,4'-(imidocbonyl)bis(n,n-dimethyl-anilin 4,4'-dimethylaminobenzophenonimide 4,4'-Bis-dimethylamino-benzophenon-imin Benzenamine, 4,4’-cbonimidoylbis [N,N-dimethyl TETRAMETHYL44DIAMINODIPHENYLMETHYLENEIMINE 4,4'-(Imidocbonyl)bis(N,N-Dimethylaniline) 4-[4-(dimethylamino)benzenecboximidoyl]-N,N-dimethylaniline Auramine free base 4-[[4-(dimethylamino)phenyl]cbonimidoyl]-N,N-dimethyl-aniline 4,4'-cbonimidoylbis[N,N-dimethyl-Benzenamine Waxoline yellow D Baso Yellow 124 Yellow pyoctenin Auramine N Base C.I. Solvent Yellow 34 4,4'-cbonimidoylbis(n,n-dimethylbenzenamine) Auramine Base 4,4'-bis-dimethylamino-benzophenone-imine Auramine SS 4,4'-Dimethylaminobenzophenonimide Orient Oil Yellow 4,4'-bis(N,N-dimethylamino)benzophenone Auramine,4,4′-Dimethylaminobenzophenone imine, Solvent Yellow 34 EINECS 207-762-5 Apyonin

Density	1.383 g/mL at 25 °C(lit.)
Boiling Point	73 °C733.4 mm Hg(lit.)
Melting Point	43 °C
Molecular Formula	C₁₇H₂₁N₃
Molecular Weight	267.36900
Flash Point	193 °F
Exact Mass	267.17400
PSA	30.33000
LogP	3.33450
Vapour density	4.38 (vs air)
Vapour Pressure	8.31E-07mmHg at 25°C
Index of Refraction	1.4400
Water Solubility	27.9 g/L (20 º C)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BY3500000

CHEMICAL NAME :: Aniline, 4,4'-(imidocarbonyl)bis(N,N-dimethyl-

CAS REGISTRY NUMBER :: 492-80-8

BEILSTEIN REFERENCE NO. :: 2215338

LAST UPDATED :: 199707

DATA ITEMS CITED :: 33

MOLECULAR FORMULA :: C17-H21-N3

MOLECULAR WEIGHT :: 267.41

WISWESSER LINE NOTATION :: 1N1&R DYUM&R DN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 103 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12 gm/kg/40D-I

TOXIC EFFECTS :: Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 mg/kg/17W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 37 gm/kg/87W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumor types after systemic administration not seen spontaneously

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 263 mg/kg/21W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 29 gm/kg/52W

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 42 gm/kg/50W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Embryo

DOSE/DURATION :: 2 mg/L

REFERENCE :: NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) No.1- 1959- Volume(issue)/page/year: 58,243,1981 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 1,69,1972 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,118,1987 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,118,1987 TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4858 No. of Facilities: 11 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 726 (estimated)

Symbol	GHS07, GHS08, GHS09
Signal Word	Warning
Hazard Statements	H302-H319-H351-H411
Precautionary Statements	P273-P281-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	Xn: Harmful;N: Dangerous for the environment;
Risk Phrases	R22
Safety Phrases	S36/37-S61
RIDADR	UN 3077 9 / PGIII
RTECS	BY3500000
HS Code	2925290090

Precursor 9
101-61-1 90-94-8 586-77-6 119-58-4
345921-89-3 58379-76-3 6083-47-2 7664-41-7
121-69-7
DownStream 3
90-94-8 603-48-5 1226-46-6

HS Code	2925290090
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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