Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4,4'-Methylenebis(N,N-dimethylaniline)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

101-61-1

101-61-1 structure

Name: 4,4'-Methylenebis(N,N-dimethylaniline)
Chemical Name: 4,4'-Methylenebis(N,N-dimethylaniline)
CAS Number: 101-61-1
Molecular Formula: C₁₇H₂₂N₂
Molecular Weight: 254.37000
Catalog: Chemical reagent Organic reagent Polyamine
Create Date: 2018-03-27 08:00:00
Modify Date: 2026-07-01 22:34:54

Name	4,4'-Methylenebis(N,N-dimethylaniline)
Synonyms	Methane base Michler's hydride p,p'-Bis(N,N-dimethylaminophenyl)methane Bis[4-(N,N-dimethylamino)phenyl]methane N,N,N',N'-tetramethyl-4,4'-diaminodiphenylmethane Methane, bis(p-(dimethylamino)phenyl) 4,4'-(Dimethylamino)diphenylmethane bazemichlerova(czech) 4,4’-methylenebis(N,N-dimethyl-Benzenamine p,p’-bis(dimethylamino)diphenylmethane Bis[p-(N,N-dimethylamino)phenyl]methane p,p'-Bis(dimethylamino)diphenylmethane 4,4'-Methanediylbis(N,N-dimethylaniline) N-(4-[4-(Dimethylamino)benzyl]phenyl)-N,N-dimethylamine Diphenylmethane, tetramethyldiamino n,n’-tetramethyldiaminodiphenylmethane N,N,N′,N′-Tetramethyl-4,4′-methylenedianiline,4,4′-Methylenebis-N,N-dimethylaniline, nolds base, N,N,N′,N′-Tetramethyl-4,4′-diaminodiphenylmethane 4,4'-BIS-(DIMETHYLAMINO)DIPHENYLMETHANE 4,4'-Tetramethyldiaminodiphenylmethane Methane, bis(4,4'-dimethylaminophenyl) 4,4'- Methylenebis-(n,n-dimethylaniline) 4,4‘-Methylenebis(N,N-dimethylaniline) METHANE BASE Benzenamine, 4,4'-methylenebis*N,N-dimethyl 4,4'-METHYLENEBIS(N,N'-DIMETHYLANILINE) 4,4'-METHYLENEBIS 4,4'-BIS(DIMETHYLAMINO)-DIPHENYLMETHANE 4,4-BIS(DIMETHYLAMINO)DIPHENYLMETHANE 4,4'-Bis(diMethylaMinophenyl)Metha Methylene base bis(p-dimethylamino)diphenylmethane Bis[4-(dimethylamino)phenyl]methane 4,4'-METHANEDIYLBIS(N,N-DIMETHYLANILINE) michler’sbase 4,4’-methylenebis(n,n-dimethyl)-benzenamine p,p-Dimethylaminodiphenylmethane Aniline, 4,4'-methylenebis[N,N-dimethyl Michler's methane 4,4'-BIS(DIMETHYLAMINO)DIPHENYL METHANE Michler's hydride 4,4′-Methylenebis(N,N-dimethylaniline),N,N,N′,N′-Tetramethyl-4,4′-diaminodiphenylmethane, N,N,N′,N′-Tetramethyl-4,4′-methylenedianiline, nolds base 4,4-METHYLENEBIS(N,N'-DIMETHYLANILINE) reducedmichler’sketone 4,4'-BIS(DIMETHYLAMINO)DIPHENYLMETHANE bis(p-(n,n-dimethylamino)phenyl)methane michler’sketone,reduced 4,4'-METHYLENE-BIS-(N,N-DIMETHYLANILINE) BIS-(4-DIMETHYLAMINOPHENYL)-METHAN Methanediamine, tetramethyl-N,N'-diphenyl michler’smethane NCI-C01990 Baze michlerova bis(p-(dimethylamino)phenyl)-methan bis(4-(n,n-dimethylamino)phenyl)methane 4,4’-methylenebis(n,n-dimethyl-benzenamin Bis[4-(dimethylamino)phenyl]methane 4,4'-Methylenebis(N,N-dimethylaniline) TETRA BASE ARNOLDS BASE 4,4-METHYLENEBIS(N,N-DIMETHYLANILINE) Methane Bas 4,4'-Tetramethyldia methylenebase 4,4-METHYLENE-BISDIMETHYLANILINE 4,4′-Methylenebis(N N,N,N′,N′-Tetramethyl-4,4′-methylenedianiline N,N,N′,N'-Tetramethyl-4,4'-diaminodiphenylmethane nolds base 4,4'-Tetramethyldiaminodiphenyl methane Bis[4-(dimethylamino)phenyl]methane 4,4'-Methylenebis(N,N-dimethylaniline) Methane Base Tetra 4,4’-(dimethylamino)diphenylmethane Bis-(4-dimethylaminophenyl)methane methylenebis(n,n-dimethylaniline) n,n,n’,n’-tetramethyl-p,p’-diaminodiphenylmethane Reduced michler'S ketone 4-{[4-(dimethylamino)phenyl]methyl}-N,N-dimethylaniline N,N,N',N'-Tetramethyl-p,p'-diaminodiphenylmethane 4,4’-methylenebis(n,n-dimethyl-anilin N,N,N',N'-tetramethyl-4,4'-methylenedianiline N,N,N’,N’-Tetramethyl-4,4’-dia n,n,n’n’-tetramethyl-p,p’-diaminodiphenylmethane MFCD00008317 N,N'-Tetramethyldiaminodiphenylmethane 4,4 -METHYLENEBIS(N,N-DIMETHYLANILINE) tetramethyldiamino-diphenylmethan 4,4’-methylenebis(n,n-dimethyl)benzenamine EINECS 202-959-2 Methane Base 4,4'-Methylenebis(N,N-dimethylaniline) Tetra Base 4,4'-Tetramethyldiaminodiphenylmethane Michler's base p,p’-bis(n,n-dimethylaminophenyl)methane bazemichlerova

Boiling Point	390 °C
Melting Point	88-89 °C(lit.)
Molecular Formula	C₁₇H₂₂N₂
Molecular Weight	254.37000
Flash Point	178 °C
Exact Mass	254.17800
PSA	6.48000
LogP	3.40940
Vapour Pressure	5.15E-08mmHg at 25°C
Index of Refraction	1.615
Storage condition	2-8°C
Water Solubility	Insoluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BY5250000

CHEMICAL NAME :: Aniline, 4,4'-methylenebis(N,N-dimethyl-

CAS REGISTRY NUMBER :: 101-61-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 40

MOLECULAR FORMULA :: C17-H22-N2

MOLECULAR WEIGHT :: 254.41

WISWESSER LINE NOTATION :: 1N1&R D1R DN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8500 mg/kg/59W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 82 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 164 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - thyroid tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 310 gm/kg/59W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 155 gm/kg/59W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - thyroid tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 683 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1365 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15488 mg/kg/59W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7744 mg/kg/59W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - thyroid tumors

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - rabbit Lymphocyte

DOSE/DURATION :: 50 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,197,1981 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,119,1982 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,119,1982 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 ppm (0.8 mg/m3);STEL 0.5 ppm JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3405 No. of Facilities: 53 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 1563 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3405 No. of Facilities: 631 (estimated) No. of Industries: 15 No. of Occupations: 9 No. of Employees: 4140 (estimated)

Symbol	GHS08, GHS09
Signal Word	Danger
Hazard Statements	H350-H410
Precautionary Statements	P201-P273-P308 + P313-P501
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T:Toxic
Risk Phrases	R45;R50/53
Safety Phrases	S53-S45-S60-S61
RIDADR	UN 3077 9/PG 3
WGK Germany	3
RTECS	BY5250000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	29215990

Precursor 10
90-94-8 121-69-7 50-00-0 119-58-4
1226-46-6 20765-67-7 109-99-9 579-10-2
108-24-7 880-09-1
DownStream 10
492-80-8 366-29-0 119-58-4 90-94-8
23970-73-2 50-00-0 547-58-0 1226-46-6
89-09-8 100-23-2

HS Code	2921590090
Summary	2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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