150113-99-8

150113-99-8 structure

Name: Decanoyl-RVKR-CMK
Chemical Name: Furin Convertase Inhibitor ( Chloromethylketone)
CAS Number: 150113-99-8
Molecular Formula: C₃₄H₆₆ClN₁₁O₅
Molecular Weight: 744.41
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2018-11-26 05:00:47
Modify Date: 2024-01-02 09:43:36
Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits over-expressed gp160 processing and HIV-1 replication[1].

Name	Furin Convertase Inhibitor ( Chloromethylketone)
Synonyms	decanoyl RVKR-CMK N-Decanoyl-N-(diaminomethylene)-L-ornithyl-L-valyl-N-{(3S)-1-chloro-6-[(diaminomethylene)amino]-2-oxo-3-hexanyl}-L-lysinamide decanoyl-Arg-Val-Lys-Arg-chloromethylketone Decanoic acid,4-formyl-2-methoxyphenyl ester L-Lysinamide, N-(diaminomethylene)-N-(1-oxodecyl)-L-ornithyl-L-valyl-N-[(1S)-1-(2-chloroacetyl)-4-[(diaminomethylene)amino]butyl]- 4-formyl-2-methoxyphenyl decanoate decanoyl vanillin decanoyl-RVKR-chloromethylketone Dec-RVKR-CMK

Description	Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits over-expressed gp160 processing and HIV-1 replication[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Research Areas >> Inflammation/Immunology
In Vitro	Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits HIV-2ROD replication by blocking envelope glycoprotein precursor processing in the Jurkat lymphocyte cell[1].Decanoyl-RVKR-CMK (DecRVKRcmk) blocks regulated secretion of VGF[2]. Cell Viability Assay Cell Line: HeLaCD4 cells infected with recombinant vaccinia viruses at a multiplicity of infection (MOI) of 5 PFU/mL[1]. Concentration: 35 and 70 µΜ. Incubation Time: 7 days. Result: Peptide at 35 µM significantly inhibited ex vivo HIV-1 and HIV-2 replications (70–80% inhibition).
References	[1]. B Bahbouhi, et al. Inhibition of HIV-2(ROD) replication in a lymphoblastoid cell line by the alpha1-antitrypsin Portland variant (alpha1-PDX) and the decRVKRcmk peptide: comparison with HIV-1(LAI). Microbes Infect. 2001 Nov;3(13):1073-84. [2]. Angelo L Garcia, et al. A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J Biol Chem. 2005 Dec 16;280(50):41595-608.