- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: 7-Deazaadenosine(Tubercidin)
- Price:
- Purity: 95.0%
- Stocking Period: 10 Day
- Contact: Huang
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: 7-Deazaadenosine(Tubercidin)
- Price: ￥1128.0/10mg ￥748.0/5mg ￥3288.0/100mg ￥2618.0/50mg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Tubercidin
- Price: $300.0/100mg $500.0/250mg $1100.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Tubercidin
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Stocking Period: 1 Day
- Contact: Tony Lai
69-33-0
69-33-0 structure
- Name: 7-Deazaadenosine(Tubercidin)
- Chemical Name: tubercidin
- CAS Number: 69-33-0
- Molecular Formula: C11H14N4O4
- Molecular Weight: 266.253
- Catalog: Biochemical Nucleoside drugs Nucleoside intermediate
- Create Date: 2018-08-25 15:17:20
- Modify Date: 2024-01-01 19:04:58
-
Tubercidin (7-Deazaadenosine) is an adenosine analog, is an antibiotic obtained from Streptomyces tubercidicus.Target: AntibacterialTubercidin inhibits the growth of Streptococcus faecalis by 50 % at a concentration of 20 nM. Tubercidin is not subject to cleavage by adenosine phosphorylase or to deamination by adenosine deaminase. The antibiotic served as a substrate for numerous enzymes involved in the anabolism of adenosine, as demonstrated by its incorporation into RNA and DNA, and by the formation of nicotinamide-deaza-adenine dinucleotide. Tubercidin proves to be a weak inhibitor of adenosine phosphorylase, and interfered with the phosphorylation of adenosine and AMP. The inhibition of the growth of S. faecalis by Tubercidin is prevented by purine and pyrimidine nucleosides, ribose 5-phosphate, pyruvate, and certain amino acids. In the presence of Tubercidin, growing cultures of the test organism used pyruvate instead of glucose, whereas in the absence of the antibiotic glucose served as the main source of energy. It is suggested, therefore, that the impairment of growth is due primarily to the interference of Tubercidin with the utilization of glucose.
| Name | tubercidin |
|---|---|
| Synonyms |
EINECS 200-703-4
Tubercidine sparsomycina 7H-pyrrolo[2,3-d]pyrimidin-4-amine, 7-β-D-ribofuranosyl- MFCD00056012 TUBERCIDIN 4-amino-7-(D-ribofuranosyl)-7H-pyrrolo{2,3-d}pyrimidine 7-Deazaadenosine Sparsomycine A |
| Description | Tubercidin (7-Deazaadenosine) is an adenosine analog, is an antibiotic obtained from Streptomyces tubercidicus.Target: AntibacterialTubercidin inhibits the growth of Streptococcus faecalis by 50 % at a concentration of 20 nM. Tubercidin is not subject to cleavage by adenosine phosphorylase or to deamination by adenosine deaminase. The antibiotic served as a substrate for numerous enzymes involved in the anabolism of adenosine, as demonstrated by its incorporation into RNA and DNA, and by the formation of nicotinamide-deaza-adenine dinucleotide. Tubercidin proves to be a weak inhibitor of adenosine phosphorylase, and interfered with the phosphorylation of adenosine and AMP. The inhibition of the growth of S. faecalis by Tubercidin is prevented by purine and pyrimidine nucleosides, ribose 5-phosphate, pyruvate, and certain amino acids. In the presence of Tubercidin, growing cultures of the test organism used pyruvate instead of glucose, whereas in the absence of the antibiotic glucose served as the main source of energy. It is suggested, therefore, that the impairment of growth is due primarily to the interference of Tubercidin with the utilization of glucose. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 648.8±55.0 °C at 760 mmHg |
| Melting Point | 247-248 °C (decomp) |
| Molecular Formula | C11H14N4O4 |
| Molecular Weight | 266.253 |
| Flash Point | 346.2±31.5 °C |
| Exact Mass | 266.101501 |
| PSA | 126.65000 |
| LogP | -0.12 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.834 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
|
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300 |
| Precautionary Statements | P264-P301 + P310 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T+: Very toxic; |
| Risk Phrases | R28 |
| Safety Phrases | S45;S36/S37/S39 |
| RIDADR | UN 3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | UY8870000 |
| Packaging Group | II |
| Hazard Class | 6.1(a) |
| HS Code | 29419090 |
| Precursor 8 | |
|---|---|
| DownStream 6 | |
![4-(methylsulfonyl)-7-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine structure](https://www.chemsrc.com/caspic/200/120401-34-5.png)
![4-Chloro-7H-pyrrolo[2,3-d]pyrimidine structure](https://www.chemsrc.com/caspic/189/3680-69-1.png)
![7-[5-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]-4-(methylthio)-7H-pyrrolo[2,3-d]pyrimidine structure](https://www.chemsrc.com/caspic/217/120401-29-8.png)
![7H-Pyrrolo[2,3-d]pyrimidine,4-(methylthio)-7-b-D-ribofuranosyl- structure](https://www.chemsrc.com/caspic/039/16754-86-2.png)
![7H-Pyrrolo[2,3-d]pyrimidine,4-methoxy-7-b-D-ribofuranosyl- structure](https://www.chemsrc.com/caspic/239/16754-81-7.png)
![1H-Pyrrolo[2,3-d]pyrimidin-4-amin structure](https://www.chemsrc.com/caspic/367/1500-85-2.png)
![1-(4-amino-pyrrolo[2,3-d]pyrimidin-7-yl)-β-D-1-deoxy-ribofuranose structure](https://www.chemsrc.com/caspic/188/72933-38-1.png)
![2-(5-dimethylamino-2,4,9-triazabicyclo[4.3.0]nona-2,4,7,10-tetraen-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol structure](https://www.chemsrc.com/caspic/489/20371-00-0.png)
![Methanimidamide,N,N-dimethyl-N'-(7-b-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)- structure](https://www.chemsrc.com/caspic/328/57881-19-3.png)
