70563-58-5

70563-58-5 structure

Name: Herbimycin A
Chemical Name: herbimycin
CAS Number: 70563-58-5
Molecular Formula: C₃₀H₄₂N₂O₉
Molecular Weight: 574.662
Catalog: API Antibiotics Other antibiotics
Create Date: 2018-10-02 11:12:45
Modify Date: 2024-01-04 12:16:11
Herbimycin A, an ansamycin antibiotic, acts as a Src family kinase inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro.

Name	herbimycin
Synonyms	2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-[(aminocarbonyl)oxy]-8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-, (4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)- herbimycin MFCD00151702 Herbimycin A (4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)-9-[(aminocarbonyl)oxy]-8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione (15R)-17-demethoxy-15-methoxy-11-O-methylgeldanamycin (4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)-8,13,14,17-Tetramethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Description	Herbimycin A, an ansamycin antibiotic, acts as a Src family kinase inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial

Density	1.2±0.1 g/cm3
Boiling Point	752.4±60.0 °C at 760 mmHg
Molecular Formula	C₃₀H₄₂N₂O₉
Molecular Weight	574.662
Flash Point	408.8±32.9 °C
Exact Mass	574.289001
PSA	152.48000
LogP	2.12
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.545
Storage condition	−20°C
Water Solubility	DMSO: 7.5 mg/mL DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 33,1114,1980

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	22-24/25-36-26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LX8930000
HS Code	29419000

Precursor 1
115929-62-9
DownStream 0

HS Code	29419000