Herbimycin A
Modify Date: 2024-01-04 12:16:11
Herbimycin A structure
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Common Name | Herbimycin A | ||
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| CAS Number | 70563-58-5 | Molecular Weight | 574.662 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 752.4±60.0 °C at 760 mmHg | |
| Molecular Formula | C30H42N2O9 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 408.8±32.9 °C | |
Use of Herbimycin AHerbimycin A, an ansamycin antibiotic, acts as a Src family kinase inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro. |
| Name | herbimycin |
|---|---|
| Synonym | More Synonyms |
| Description | Herbimycin A, an ansamycin antibiotic, acts as a Src family kinase inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro. |
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| Related Catalog |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 752.4±60.0 °C at 760 mmHg |
| Molecular Formula | C30H42N2O9 |
| Molecular Weight | 574.662 |
| Flash Point | 408.8±32.9 °C |
| Exact Mass | 574.289001 |
| PSA | 152.48000 |
| LogP | 2.12 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.545 |
| Storage condition | −20°C |
| Water Solubility | DMSO: 7.5 mg/mL DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1. |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 22-24/25-36-26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | LX8930000 |
| HS Code | 29419000 |
| Precursor 1 | |
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| DownStream 0 | |
CAS#:115929-62-9| HS Code | 29419000 |
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Herbimycins D-F, ansamycin analogues from Streptomyces sp. RM-7-15.
J. Nat. Prod. 76(9) , 1619-26, (2013) Bacterial strains belonging to the class actinomycetes were isolated from the soil near a thermal vent of the Ruth Mullins coal fire (Appalachian Mountains of eastern Kentucky). High-resolution electr... |
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Herbimycin A inhibits cell growth with reversal of epithelial-mesenchymal transition in anaplastic thyroid carcinoma cells.
Biochem. Biophys. Res. Commun. 455(3-4) , 363-70, (2014) We aimed to elucidate the effect of herbimycin A (HMA), a heat shock protein 90 inhibitor, on cell growth and epithelial-mesenchymal transition (EMT) in anaplastic thyroid carcinoma (ATC) cells. HMA i... |
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Effects of tyrosine kinase and phosphatase inhibitors on microtubules in Arabidopsis root cells.
Cell Biol. Int. 32(6) , 630-7, (2008) To investigate the role of tyrosine phosphorylation/dephosphorylation processes in plant cells the morphology of Arabidopsis thaliana primary roots and the organization of cortical microtubules (MTs) ... |
| 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-[(aminocarbonyl)oxy]-8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-, (4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)- |
| herbimycin |
| MFCD00151702 |
| Herbimycin A |
| (4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)-9-[(aminocarbonyl)oxy]-8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione |
| (15R)-17-demethoxy-15-methoxy-11-O-methylgeldanamycin |
| (4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)-8,13,14,17-Tetramethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate |