Name | cyproheptadine |
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Synonyms |
cyproheptadiene
EINECS 204-928-9 Dronactin Periactine Periactinol MFCD00242817 Eiproheptadine Cyproheptadine 1-methyl-4-(5-dibenzo[a,e]cycloheptatrienylidene)piperidine MK 141 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine Periactin Cypoheptadine 4-dibenzo[a,d]cyclohepten-5-ylidene-1-methyl-piperidine Periactin(R) |
Description | Cyproheptadine is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine has antiplatelet and thromboprotective activities. Cyproheptadine can be used for the research of thromboembolic disorders[1][2]. |
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Related Catalog | |
In Vitro | Cyproheptadine (0.01-100 nM; 1 minute) dose-dependently inhibits serotonin-enhanced ADP-induced mouse platelet aggregation in vitro[2]. Cyproheptadine (10 nM) has the ability to inhibit 15 µM serotonin-enhanced ADP-induced (1 µM) tyrosine phosphorylation in platelets in vitro[2]. Cyproheptadine inhibits human platelet PS exposure (Annexin V), P-selectin, and GPIIb-IIIa (PAC-1 binding) activation in vitro[2]. |
In Vivo | Cyproheptadine (1 mg/kg; i.p.; daily, for 5 days; C57BL/6 mice) exerts thromboprotective properties in vivo[2]. Animal Model: C57BL/6 mice (8-10 weeks old)[2] Dosage: 1 mg/kg Administration: Intraperitoneal injection; daily, for 5 days Result: Prolonged occlusion times and tail bleeding times in mice. |
References |
[1]. Calka O, et, al. Effect of cyproheptadine on serum leptin levels. Adv Ther, 2005. 22(5): p. 424-8. |
Density | 1.115g/cm3 |
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Boiling Point | 440.1ºC at 760mmHg |
Melting Point | 298 °C (dec.)(lit.) |
Molecular Formula | C21H22ClN |
Molecular Weight | 323.85900 |
Flash Point | 194.5ºC |
Exact Mass | 323.14400 |
PSA | 3.24000 |
LogP | 5.43780 |
Vapour Pressure | 6.03E-08mmHg at 25°C |
Index of Refraction | 1.5339 (20ºC) |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Packaging Group | I; II; III |
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HS Code | 29143900 |
~99% 129-03-3 |
Literature: Hatano, Manabu; Ito, Orie; Suzuki, Shinji; Ishihara, Kazuaki Journal of Organic Chemistry, 2010 , vol. 75, # 15 p. 5008 - 5016 |
~% 129-03-3 |
Literature: Archiv der Pharmazie, , vol. 329, # 2 p. 87 - 94 |
~% 129-03-3 |
Literature: Tetrahedron, , vol. 44, # 19 p. 6197 - 6200 |
~% 129-03-3 |
Literature: Tetrahedron, , vol. 44, # 19 p. 6197 - 6200 |
~% 129-03-3 |
Literature: Archiv der Pharmazie, , vol. 329, # 2 p. 87 - 94 |
Precursor 5 | |
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DownStream 2 | |
HS Code | 2933399090 |
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Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |