Cyproheptadine

Modify Date: 2026-07-08 17:43:37

Cyproheptadine structure	Common Name	Cyproheptadine
	CAS Number	129-03-3	Molecular Weight	287.4
	Density	1.115g/cm3	Boiling Point	440.1ºC at 760mmHg
	Molecular Formula	C₂₁H₂₁N	Melting Point	298 °C (dec.)(lit.)
	MSDS	N/A	Flash Point	194.5ºC

Use of Cyproheptadine

Cyproheptadine is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine has antiplatelet and thromboprotective activities. Cyproheptadine can be used for the research of thromboembolic disorders[1][2].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	cyproheptadine
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Cyproheptadine is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine has antiplatelet and thromboprotective activities. Cyproheptadine can be used for the research of thromboembolic disorders[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cardiovascular Disease Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
In Vitro	Cyproheptadine (0.01-100 nM; 1 minute) dose-dependently inhibits serotonin-enhanced ADP-induced mouse platelet aggregation in vitro[2]. Cyproheptadine (10 nM) has the ability to inhibit 15 µM serotonin-enhanced ADP-induced (1 µM) tyrosine phosphorylation in platelets in vitro[2]. Cyproheptadine inhibits human platelet PS exposure (Annexin V), P-selectin, and GPIIb-IIIa (PAC-1 binding) activation in vitro[2].
In Vivo	Cyproheptadine (1 mg/kg; i.p.; daily, for 5 days; C57BL/6 mice) exerts thromboprotective properties in vivo[2]. Animal Model: C57BL/6 mice (8-10 weeks old)[2] Dosage: 1 mg/kg Administration: Intraperitoneal injection; daily, for 5 days Result: Prolonged occlusion times and tail bleeding times in mice.
References	[1]. Calka O, et, al. Effect of cyproheptadine on serum leptin levels. Adv Ther, 2005. 22(5): p. 424-8. [2]. Olivia A Lin, et al. The Antidepressant 5-HT2A Receptor Antagonists Pizotifen and Cyproheptadine Inhibit Serotonin-Enhanced Platelet Function. PLoS One. 2014; 9(1): e87026.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.115g/cm3
Boiling Point	440.1ºC at 760mmHg
Melting Point	298 °C (dec.)(lit.)
Molecular Formula	C₂₁H₂₁N
Molecular Weight	287.4
Flash Point	194.5ºC
Exact Mass	287.167399674
PSA	3.24000
LogP	5.43780
Vapour Pressure	6.03E-08mmHg at 25°C
Index of Refraction	1.5339 (20ºC)
InChIKey	JJCFRYNCJDLXIK-UHFFFAOYSA-N
SMILES	CN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM7000000

CHEMICAL NAME :: Piperidine, 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methyl-

CAS REGISTRY NUMBER :: 129-03-3

BEILSTEIN REFERENCE NO. :: 1685976

LAST UPDATED :: 199706

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C21-H21-N

MOLECULAR WEIGHT :: 287.43

WISWESSER LINE NOTATION :: L C676 BYJ BU- DT6N DYTJ A1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 295 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,69,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 52 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,69,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 106 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 43300 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 107 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,69,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,82,1973

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,69,1972 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 10 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 257,168,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 20 mg/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 257,168,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 20 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 257,168,1982

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Packaging Group	I; II; III
HS Code	29143900

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

5-(1-Methyl-4-P...

CAS#:3967-32-6

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Cyproheptadine

CAS#:129-03-3

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Dibenzosuberenone

CAS#:2222-33-5

Cyproheptadine

CAS#:129-03-3

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Literature: Archiv der Pharmazie, , vol. 329, # 2 p. 87 - 94

ethyl 4-(5H-dib...

CAS#:121138-82-7

Cyproheptadine

CAS#:129-03-3

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Literature: Tetrahedron, , vol. 44, # 19 p. 6197 - 6200

N-Carbethoxy-4-...

CAS#:29976-53-2

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CAS#:129-03-3

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Literature: Tetrahedron, , vol. 44, # 19 p. 6197 - 6200

magnesium,1-met...

CAS#:63463-36-5

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Literature: Archiv der Pharmazie, , vol. 329, # 2 p. 87 - 94

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 5
CAS#:3967-32-6 5-(1-Methyl-4-P... CAS#:2222-33-5 Dibenzosuberenone CAS#:121138-82-7 ethyl 4-(5H-dib... CAS#:29976-53-2 N-Carbethoxy-4-...
CAS#:63463-36-5 magnesium,1-met...
DownStream 2
CAS#:14051-46-8 desmethylcyproh... CAS#:54191-04-7 cyproheptadine ...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-keats_OPM1-m4-1

Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-OC1MY5-m4-1

Name: Inhibition of Dot1L (unknown origin) by AlphaELISA
Source: ChEMBL
Target: Histone-lysine N-methyltransferase, H3 lysine-79 specific
External Id: CHEMBL3812799

Name: Inhibition of Set8 (unknown origin) by AlphaELISA
Source: ChEMBL
Target: N-lysine methyltransferase KMT5A
External Id: CHEMBL3812798

Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625

Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-KMS_34-m4-1

Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-keats_L363-m4-1

Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-keats_OCIMY7-m4-1

Total 743, Current Page 1 of 75

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

cyproheptadiene

EINECS 204-928-9

Dronactin

Periactine

Periactinol

MFCD00242817

Eiproheptadine

Cyproheptadine

1-methyl-4-(5-dibenzo[a,e]cycloheptatrienylidene)piperidine

MK 141

4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine

Periactin

Cypoheptadine

4-dibenzo[a,d]cyclohepten-5-ylidene-1-methyl-piperidine

Periactin(R)

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the polar surface area (PSA) of cyproheptadine?

A: Polar surface area (PSA) of cyproheptadine is 3.24000.

Q: What is the CAS number of cyproheptadine?

A: CAS number of cyproheptadine is 129-03-3.

Q: What is the SMILES notation of cyproheptadine?

A: SMILES notation of cyproheptadine is CN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1.

Q: What are the upstream materials of cyproheptadine?

A: Related upstream materials(CAS) of cyproheptadine: 3967-32-6;2222-33-5;121138-82-7;29976-53-2;63463-36-5.

Q: What are the uses of cyproheptadine?

A: Main uses of cyproheptadine: Cyproheptadine is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine has antiplatelet and thromboprotective activities. Cyproheptadine can be used for the research of thromboembolic disorders[1][2].

Q: What is the InChIKey of cyproheptadine?

A: InChIKey of cyproheptadine is JJCFRYNCJDLXIK-UHFFFAOYSA-N.

Q: What are the downstream products of cyproheptadine?

A: Related downstream products(CAS) of cyproheptadine: 14051-46-8;54191-04-7.

Q: What is the molecular weight of cyproheptadine?

A: Molecular weight of cyproheptadine is 287.4.

Q: What is the boiling point of cyproheptadine?

A: Boiling point of cyproheptadine is 440.1ºC at 760mmHg.

Q: What is the English name of cyproheptadine?

A: The English name of cyproheptadine is cyproheptadine.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Cyproheptadine
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Cyproheptadine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFUCHEM--129-03-3--Cyproheptadine in stock
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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