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58994-96-0

58994-96-0 structure
58994-96-0 structure
  • Name: ranimustine
  • Chemical Name: Ranimustine
  • CAS Number: 58994-96-0
  • Molecular Formula: C10H18ClN3O7
  • Molecular Weight: 327.71900
  • Catalog: API Antineoplastic agents Alkylating agent
  • Create Date: 2018-02-22 08:00:00
  • Modify Date: 2024-01-08 18:29:31
  • Ranimustine (MCNU) is a nitrosourea alkylating agent, can be used for research of chronic myelogenous leukemia and polycythemia vera[1][3][4].
Name Ranimustine
Synonyms Cymerin
MCNU
MFCD00866369
Thymerin
RCL L16,919-6
1-(2-chloroethyl)-1-nitroso-3-[[(2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-methoxy-oxan-2-yl]methyl]urea
Ranomustine
Description Ranimustine (MCNU) is a nitrosourea alkylating agent, can be used for research of chronic myelogenous leukemia and polycythemia vera[1][3][4].
Related Catalog
In Vivo Ranimustine reduces spermidine and spermine in the corpus striatum, and spermine in the diencephalon, but increases putrescine in the corpus striatum and combined thalamus and hypothalamus[2].
Density 1.69 g/cm3
Molecular Formula C10H18ClN3O7
Molecular Weight 327.71900
Exact Mass 327.08300
PSA 140.92000
Index of Refraction 1.616

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LZ5910000
CHEMICAL NAME :
Glucopyranoside, methyl-6-((((2-chloroethyl)nitrosoamino)carbonyl)amin o)-6-deoxy-, alpha-D-
CAS REGISTRY NUMBER :
58994-96-0
LAST UPDATED :
199612
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C10-H18-Cl-N3-O7
MOLECULAR WEIGHT :
327.76
WISWESSER LINE NOTATION :
T6OTJ BO1 CQ DQ EQ F1MVNNO&2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
46400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
37 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
31800 ug/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
45700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
39 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
41200 ug/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
5 mg/kg
SEX/DURATION :
female 5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Rodent - mouse Leukocyte
DOSE/DURATION :
10 mg/L
REFERENCE :
AMKUDT Acta Medica Kinki University. (Kinki Univ. Medical Assoc., 380 Nishiyama, Sayama-cho, Minami-kawachi-gun, Osaka-fu, Japan) V.1- 1976- Volume(issue)/page/year: 11,57,1986
Hazard Codes T
Risk Phrases R25:Toxic if swallowed. R41:Risk of serious damage to eyes. R43:May cause sensitization by skin contact.
Safety Phrases S26-S36/37/39-S45
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS XU7700000
Packaging Group III
Hazard Class 6.1
58994-95-9 structure

58994-95-9

~42%

58994-96-0 structure

58994-96-0

Literature: Sosnovsky; Rao Journal of Pharmaceutical Sciences, 1991 , vol. 80, # 7 p. 693 - 699
5155-43-1 structure

5155-43-1

~%

58994-96-0 structure

58994-96-0

Literature: Sosnovsky; Rao Journal of Pharmaceutical Sciences, 1991 , vol. 80, # 7 p. 693 - 699
Precursor  2

DownStream  0


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