119817-90-2

119817-90-2 structure

Name: Dexloxiglumide
Chemical Name: (4R)-4-[(3,4-dichlorobenzoyl)amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic acid
CAS Number: 119817-90-2
Molecular Formula: C₂₁H₃₀Cl₂N₂O₅
Molecular Weight: 461.37900
Catalog: Signaling Pathways GPCR/G Protein Cholecystokinin Receptor
Create Date: 2018-06-13 17:43:17
Modify Date: 2026-07-08 15:42:17
Dexloxiglumide is a selective cholecystokinin type A (CCKA) receptor antagonist[1]. Dexloxiglumide, the active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8)[2].

Name	(4R)-4-[(3,4-dichlorobenzoyl)amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic acid
Synonyms	5-((3-methoxypropyl) CR-2017 Dexloxiglumidum (R)-4-(3,4-Dichlorobenzoylamino)-5-[(3-methoxypropyl)pentylamino]-5-oxopentanoic acid Dexloxiglumida Dexloxiglumida [INN-Spanish] pentanoic acid, 4-[(3,4-dichlorobenzoyl)amino]-5-[(3-methoxypropyl)pentylamino]-5-oxo-, (4r) (4R)-4-[[(3,4-dichlorophenyl)-oxomethyl]amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic acid Dexloxiglumidum [INN-Latin] 4-(3,4-Dichlorobenzamido) (4r)-4-[(3,4-dichlorobenzoyl)amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic Acid (R)-4-(3,4-DichlorobenzaMido)-5-((3-Methoxypropyl)(pentyl)amino)-5-oxopentanoic acid

Description	Dexloxiglumide is a selective cholecystokinin type A (CCKA) receptor antagonist[1]. Dexloxiglumide, the active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8)[2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Cholecystokinin Receptor Research Areas >> Metabolic Disease
References	[1]. Scarpignato C, et al. Effect of dexloxiglumide and spiroglumide, two new CCK-receptor antagonists, on gastric emptying and secretion in the rat: evaluation of their receptor selectivity in vivo. Aliment Pharmacol Ther. 1996 Jun;10(3):411-9. [2]. Maselli MA, et al. CCK1 receptor antagonist, dexloxiglumide: effects on human isolated gallbladder. Potential clinical applications. Minerva Gastroenterol Dietol. 2003 Sep;49(3):211-6.

Hazard Codes	Xn,Xi