Shanghai Nianxing Industrial Co., Ltd
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Dayang Chem (Hangzhou) Co., Ltd.
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Henan Tianfu Chemical Co., Ltd.
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7786-61-0

7786-61-0 structure

7786-61-0 structure

Name: 4-Hydroxy-3-methoxystyrene
Chemical Name: 2-methoxy-4-vinylphenol
CAS Number: 7786-61-0
Molecular Formula: C₉H₁₀O₂
Molecular Weight: 150.174
Catalog: Flavors and spices Synthetic spice Phenols, ethers and epoxides Phenols
Create Date: 2018-06-12 17:12:17
Modify Date: 2024-01-02 23:30:57
2-Methoxy-4-vinylphenol (2M4VP), a naturally Germination inhibitor, exerts potent anti-inflammatory effects[1][2].

Name	2-methoxy-4-vinylphenol
Synonyms	p-Vinyl guaiacol p-vinylguaiacol MFCD00015437 3-06-00-04981 (Beilstein Handbook Reference) o-Methoxy-p-vinylphenol 2-Methoxy-4-vinylphenol Phenol, 2-methoxy-4-vinyl- Phenol, 4-ethenyl-2-methoxy- 4-Hydroxy-3-methoxystyrene 2-Methoxy-4-ethenylphenol EINECS 232-101-2 2-METHOXY-4-VINYL-PHENOL 3-Methoxy-4-hydroxystyrene 4-ETHENYL-2-METHOXYPHENOL 4-VINYLGUAIACOL

Description	2-Methoxy-4-vinylphenol (2M4VP), a naturally Germination inhibitor, exerts potent anti-inflammatory effects[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	2-Methoxy-4-vinylphenol (2M4VP) potently inhibits the translocation of NF-κB p65 into the nucleus by IκB degradation following IκB-α phosphorylation and the phosphorylation of MAPKs such as p38, ERK1/2, and JNK[1]. 2-Methoxy-4-vinylphenol (2M4VP) inhibits hyper-acetylation of histone H3 (Lys9/Lys14) induced by LPS[1]. Western Blot Analysis[1] Cell Line: RAW264.7 cells. Concentration: 0-40 μM. Incubation Time: 24 h. Result: Inhibited the over-expression of iNOS and COX-2 protein in LPS-stimulated RAW264.7 cells.
References	[1]. Jin Boo Jeong, et al. Anti-inflammatory Effect of 2-methoxy-4-vinylphenol via the Suppression of NF-κB and MAPK Activation, and Acetylation of Histone H3. Arch Pharm Res. 2011 Dec;34(12):2109-16. [2]. Hossein Reza Darabi, et al. A Structure-Activity Relationship Study on a Natural Germination Inhibitor, 2-methoxy-4-vinylphenol (MVP), in Wheat Seeds to Evaluate Its Mode of Action. Z Naturforsch C J Biosci. Sep-Oct 2007;62(9-10):694-700.

Density	1.1±0.1 g/cm3
Boiling Point	245.0±20.0 °C at 760 mmHg
Melting Point	25-29°C
Molecular Formula	C₉H₁₀O₂
Molecular Weight	150.174
Flash Point	111.3±6.7 °C
Exact Mass	150.068085
PSA	29.46000
LogP	1.93
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.578
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL8205000

CHEMICAL NAME :: Phenol, 2-methoxy-4-vinyl-

CAS REGISTRY NUMBER :: 7786-61-0

BEILSTEIN REFERENCE NO. :: 2044521

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H10-O2

MOLECULAR WEIGHT :: 150.19

WISWESSER LINE NOTATION :: 1U1R DQ CO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1400 mg/kg

SEX/DURATION :: female 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - other measures of fertility

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 500 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 206,17,1988

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	SL8205000
HS Code	2909500000

Precursor 9
141-82-2 121-33-5 1779-49-3 1135-24-6
97-53-0 54509-73-8 46316-15-8 2480-86-6
97-54-1
DownStream 10
121-33-5 1206103-25-4 751-38-2 2785-89-9
7417-21-2 6380-23-0 55708-65-1 64881-05-6
77891-29-3 828269-23-4

HS Code	2909500000
Summary	2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%