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1247-42-3

1247-42-3 structure
1247-42-3 structure
  • Name: meprednisone
  • Chemical Name: Meprednisone
  • CAS Number: 1247-42-3
  • Molecular Formula: C22H28O5
  • Molecular Weight: 372.455
  • Catalog: API Hormone and endocrine-regulating drugs Adrenal corticosteroids
  • Create Date: 2018-09-15 08:18:27
  • Modify Date: 2025-08-20 07:21:09
  • Meprednisone is a glucocorticoid and a methylated derivative of prednisone.Target: Glucocorticoid ReceptorMeprednisone is a glucocorticoid and a methylated derivative of prednisone. The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to altered interconversion between these steroids. An improved pharmacokinetic/dynamic receptor/gene-mediated model characterized the steroid receptor binding and induction of tyrosine aminotransferase activity after i.v. MPL sodium succinate (10 mg/kg). In contrast to previous in vitro studies, ketoconazole at maximally tolerated doses failed to antagonize the steroid receptor-mediated activity of MPL [1].
Name Meprednisone
Synonyms (16b)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione
16β-Methylprednisone
methylprednisone
deltisonab
(16β)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione
Deltisona B
16b-Methylprednisone
Betapred
Betalone
Betapar
Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-methyl-, (16β)-
17,21-Dihydroxy-16β-methylpregna-1,4-diene-3,11,20-trione
meprednisone
17,21-Dihydroxy-16b-methylpregna-1,4-diene-3,11,20-trione
Bitanisone
Betanisona
Description Meprednisone is a glucocorticoid and a methylated derivative of prednisone.Target: Glucocorticoid ReceptorMeprednisone is a glucocorticoid and a methylated derivative of prednisone. The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to altered interconversion between these steroids. An improved pharmacokinetic/dynamic receptor/gene-mediated model characterized the steroid receptor binding and induction of tyrosine aminotransferase activity after i.v. MPL sodium succinate (10 mg/kg). In contrast to previous in vitro studies, ketoconazole at maximally tolerated doses failed to antagonize the steroid receptor-mediated activity of MPL [1].
Related Catalog
References

[1]. Scheuer, E. and E. Warshaw, Allergy to corticosteroids: update and review of epidemiology, clinical characteristics, and structural cross-reactivity. Am J Contact Dermat, 2003. 14(4): p. 179-87.
Density 1.3±0.1 g/cm3
Boiling Point 574.4±50.0 °C at 760 mmHg
Melting Point 204-206ºC
Molecular Formula C22H28O5
Molecular Weight 372.455
Flash Point 315.2±26.6 °C
Exact Mass 372.193665
PSA 91.67000
LogP 2.06
Vapour Pressure 0.0±3.6 mmHg at 25°C
Index of Refraction 1.595
Storage condition 2~8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU4154090
CHEMICAL NAME :
Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-beta-methyl-
CAS REGISTRY NUMBER :
1247-42-3
LAST UPDATED :
198910
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C22-H28-O5
MOLECULAR WEIGHT :
372.50
WISWESSER LINE NOTATION :
L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ G1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
14 mg/kg
SEX/DURATION :
female 16-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 30,1098,1974
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
6250 ug/kg
SEX/DURATION :
female 15-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1967- Volume(issue)/page/year: 11,1042,1977
RIDADR NONH for all modes of transport
HS Code 2937210000
1106-03-2 structure

1106-03-2

~%

1247-42-3 structure

1247-42-3

Literature: Journal of the American Chemical Society, , vol. 80, p. 4428 Journal of the American Chemical Society, , vol. 80, p. 4435 Journal of the American Chemical Society, , vol. 82, p. 4012,4025
1253-36-7 structure

1253-36-7

~%

1247-42-3 structure

1247-42-3

Literature: Journal of the American Chemical Society, , vol. 80, p. 4428 Journal of the American Chemical Society, , vol. 80, p. 4435 Journal of the American Chemical Society, , vol. 82, p. 4012,4025
Precursor  1

DownStream  0

HS Code 2937210000
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