1674-62-0

1674-62-0 structure
1674-62-0 structure

Name 1-Methylbiguanide monohydrochloride
Synonyms 1-(diaminomethylidene)-2-methylguanidine,hydrochloride
Metformin Related Compound B
1-Methylbiguanide hyrdochloride (Metformin RCB)
Metformin Impurity 5(HCl)
Density 1.45g/cm3
Boiling Point 295.3ºC at 760mmHg
Molecular Formula C3H10ClN5
Molecular Weight 151.59800
Flash Point 132.4ºC
Exact Mass 151.06200
PSA 97.78000
LogP 1.10720
Vapour Pressure 0.00154mmHg at 25°C
Index of Refraction 1.624

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DU2042000
CHEMICAL NAME :
Biguanide, 1-methyl-, monohydrochloride
CAS REGISTRY NUMBER :
1674-62-0
LAST UPDATED :
198702
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C3-H9-N5.Cl-H
MOLECULAR WEIGHT :
151.63
WISWESSER LINE NOTATION :
MUYZMYUM&M1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1754 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 15,521,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
325 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 15,521,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,314,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 6,117,1974
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
RIDADR NONH for all modes of transport
Precursor  0

DownStream  5