Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Oxotremorine sesquifumarate
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DC Chemicals Limited
China
Product Name: Oxotremorine sesquifumarate
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: OXOTREMORINE SESQUIFUMARATE
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Purity: 98.0%
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17360-35-9

17360-35-9 structure

17360-35-9 structure

Name: Oxotremorine sesquifumarate
Chemical Name: Oxotremorine sesquifumarate salt
CAS Number: 17360-35-9
Molecular Formula: C₃₆H₄₈N₄O₁₄
Molecular Weight: 760.78500
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2018-11-29 16:56:39
Modify Date: 2024-01-12 21:39:53
Oxotremorine sesquifumarate is a mAChR agonist that mainly activates M2 receptors. Oxotremorine sesquifumarate can be used for neurological research[1][2].

Name	Oxotremorine sesquifumarate salt
Synonyms	EINECS 241-388-3 MFCD00013163 1-(4-[1-Pyrrolidinyl]-2-butynyl)-2-pyrrolidinone 1-(4-[1-Pyrrolidinyl]2-butynyl)-2-pyrrolidinone Oxotremorine sesquifumarate,1-[4-(1-Pyrrolidinyl)-2-butynyl]-2-pyrrolidinonesesquifumarate

Description	Oxotremorine sesquifumarate is a mAChR agonist that mainly activates M2 receptors. Oxotremorine sesquifumarate can be used for neurological research[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
In Vitro	Oxotremorine (10.5 μM) produces a paralytic effect on twitch responses of rat diaphragm in vitro to direct and indirect stimulation[1].
In Vivo	In rats with sciatic nerve injuries, Oxotremorine (10, 5, 2 1 μg; 10 μL) i.t. dose-dependently suppresses the tactile hypersensitivity[2].
References	[1]. M Das, D K Ganguly, et al. Enhancement by oxotremorine of acetylcholine release from the rat phrenic nerve. Br J Pharmacol. 1978 Feb;62(2):195-8. [2]. Zhiyang Song, et al. Muscarinic receptor activation potentiates the effect of spinal cord stimulation on pain-related behavior in rats with mononeuropathy. Neurosci Lett. 2008 May 2;436(1):7-12.

Boiling Point	373.9ºC at 760 mmHg
Melting Point	102-105ºC(lit.)
Molecular Formula	C₃₆H₄₈N₄O₁₄
Molecular Weight	760.78500
Flash Point	169.1ºC
Exact Mass	760.31700
PSA	270.90000
LogP	0.30300
Vapour Pressure	8.7E-06mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY6000000

CHEMICAL NAME :: 2-Pyrrolidinone, 1-(4-(1-pyrrolidinyl)-2-butynyl)-, sesquifumarate

CAS REGISTRY NUMBER :: 17360-35-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C12-H18-N2-O.3/2C4-H4-O4

MOLECULAR WEIGHT :: 380.44

WISWESSER LINE NOTATION :: T5NVTJ A2UU2- AT5NTJ &QV1U1VQ -C

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 28,227,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04243 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21 mg/kg/7D-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases

REFERENCE :: DTESD7 52 Vanderbilt Ave., New York, NY 10017) V.1-15, 1977-87. Discontinued 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977- Volume(issue)/page/year: 11,495,1983

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300-H310-H330
Precautionary Statements	P260-P264-P280-P284-P302 + P350-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+
Risk Phrases	26/27/28
Safety Phrases	S28;S45;S36/S37
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	UY6000000
Packaging Group	I
Hazard Class	6.1(a)

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