121932-06-7

121932-06-7 structure

Name: PKA Inhibitor Fragment (6-22) amide
Chemical Name: Protein Kinase A Inhibitor Fragment 6-22 amide
CAS Number: 121932-06-7
Molecular Formula: C₈₀H₁₃₀N₂₈O₂₄
Molecular Weight: 1868.06000
Catalog: Biochemical Peptide
Create Date: 2018-10-04 13:42:27
Modify Date: 2024-01-08 02:55:11
PKA Inhibitor Fragment (6-22) amide is an inhibitor of cAMP-dependent protein kinase A (PKA), with a Ki of 2.8 nM. PKA Inhibitor Fragment (6-22) amide can significantly reverse low-level morphine antinociceptive tolerance in mice[1][2].

Name	Protein Kinase A Inhibitor Fragment 6-22 amide
Synonyms	Protein Kinase A Inhibitor Fragment 6-22 amide PKA inhibitor fragment (6-22) amide MFCD00133792

Description	PKA Inhibitor Fragment (6-22) amide is an inhibitor of cAMP-dependent protein kinase A (PKA), with a Ki of 2.8 nM. PKA Inhibitor Fragment (6-22) amide can significantly reverse low-level morphine antinociceptive tolerance in mice[1][2].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Research Areas >> Neurological Disease
Target	PKA:2.8 nM (Ki)
References	[1]. Katz BM, et, al. Synthesis, characterization and inhibitory activities of (4-N3[3,5-3H]Phe10)PKI(6-22)amide and its precursors: photoaffinity labeling peptides for the active site of cyclic AMP-dependent protein kinase. Int J Pept Protein Res. 1989 Jun;33(6):439 [2]. Dalton GD, et, al. Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI). Neuropharmacology. 2005 Apr; 48(5): 648-57.

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