PKA Inhibitor Fragment (6-22) amide
Modify Date: 2025-08-23 16:13:41
PKA Inhibitor Fragment (6-22) amide structure
|
Common Name | PKA Inhibitor Fragment (6-22) amide | ||
|---|---|---|---|---|
| CAS Number | 121932-06-7 | Molecular Weight | 1868.06000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C80H130N28O24 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of PKA Inhibitor Fragment (6-22) amidePKA Inhibitor Fragment (6-22) amide is an inhibitor of cAMP-dependent protein kinase A (PKA), with a Ki of 2.8 nM. PKA Inhibitor Fragment (6-22) amide can significantly reverse low-level morphine antinociceptive tolerance in mice[1][2]. |
| Name | Protein Kinase A Inhibitor Fragment 6-22 amide |
|---|---|
| Synonym | More Synonyms |
| Description | PKA Inhibitor Fragment (6-22) amide is an inhibitor of cAMP-dependent protein kinase A (PKA), with a Ki of 2.8 nM. PKA Inhibitor Fragment (6-22) amide can significantly reverse low-level morphine antinociceptive tolerance in mice[1][2]. |
|---|---|
| Related Catalog | |
| Target |
PKA:2.8 nM (Ki) |
| References |
| Molecular Formula | C80H130N28O24 |
|---|---|
| Molecular Weight | 1868.06000 |
| Exact Mass | 1866.98000 |
| PSA | 881.72000 |
| InChIKey | VAKHFAFLRUNHLQ-PEBJKXEYSA-N |
| SMILES | CCC(C)C(NC(=O)C(C)NC(=O)C(CC(N)=O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(CO)NC(=O)C(C)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(N)C(C)O)C(C)CC)C(C)O)C(N)=O |
| Storage condition | −20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
|
Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. Inhibition of cAMP-dependent protein kinase.
J. Biol. Chem. 264 , 14579, (1989) The minimal structure in the heat-stable inhibitor protein of cAMP-dependent protein kinase required for a low nanomolar potency of inhibition is the peptide Thr6-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-T... |
| Protein Kinase A Inhibitor Fragment 6-22 amide |
| PKA inhibitor fragment (6-22) amide |
| MFCD00133792 |