PKA Inhibitor Fragment (6-22) amide

Modify Date: 2024-01-08 02:55:11

PKA Inhibitor Fragment (6-22) amide structure	Common Name	PKA Inhibitor Fragment (6-22) amide
	CAS Number	121932-06-7	Molecular Weight	1868.06000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₈₀H₁₃₀N₂₈O₂₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of PKA Inhibitor Fragment (6-22) amide

PKA Inhibitor Fragment (6-22) amide is an inhibitor of cAMP-dependent protein kinase A (PKA), with a Ki of 2.8 nM. PKA Inhibitor Fragment (6-22) amide can significantly reverse low-level morphine antinociceptive tolerance in mice[1][2].

Name	Protein Kinase A Inhibitor Fragment 6-22 amide
Synonym	More Synonyms

Description	PKA Inhibitor Fragment (6-22) amide is an inhibitor of cAMP-dependent protein kinase A (PKA), with a Ki of 2.8 nM. PKA Inhibitor Fragment (6-22) amide can significantly reverse low-level morphine antinociceptive tolerance in mice[1][2].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Research Areas >> Neurological Disease
Target	PKA:2.8 nM (Ki)
References	[1]. Katz BM, et, al. Synthesis, characterization and inhibitory activities of (4-N3[3,5-3H]Phe10)PKI(6-22)amide and its precursors: photoaffinity labeling peptides for the active site of cyclic AMP-dependent protein kinase. Int J Pept Protein Res. 1989 Jun;33(6):439 [2]. Dalton GD, et, al. Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI). Neuropharmacology. 2005 Apr; 48(5): 648-57.

Molecular Formula	C₈₀H₁₃₀N₂₈O₂₄
Molecular Weight	1868.06000
Exact Mass	1866.98000
PSA	881.72000
Storage condition	−20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. Inhibition of cAMP-dependent protein kinase.

J. Biol. Chem. 264 , 14579, (1989)

The minimal structure in the heat-stable inhibitor protein of cAMP-dependent protein kinase required for a low nanomolar potency of inhibition is the peptide Thr6-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-T...

Protein Kinase A Inhibitor Fragment 6-22 amide

PKA inhibitor fragment (6-22) amide

MFCD00133792

PKA Inhibitor Fragment (6-22) amide

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