475498-26-1

475498-26-1 structure

Name: MCL 0020
Chemical Name: DPPE fumarate
CAS Number: 475498-26-1
Molecular Formula: C₃₄H₃₉N₇O₄
Molecular Weight: 609.71800
Catalog: Research Areas Inflammation/Immunology
Create Date: 2017-08-20 11:19:47
Modify Date: 2024-01-02 18:18:23
MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM. MCL0020 dose-dependently and significantly attenuates restraint stress-induced anorexia without affecting food intake[1].

Name	DPPE fumarate

Description	MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM. MCL0020 dose-dependently and significantly attenuates restraint stress-induced anorexia without affecting food intake[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Melanocortin Receptor
Target	IC50: 11.63 (MC4)
In Vitro	MCL0020 inhibited [125I][N1e4, D-Phe7]α-MSH binding to membranes of COS-1 cells with IC50 values of 11.63[1].
In Vivo	MCL0020 attenuates swim stress-induced anxiogeniclike behavior in light/dark exploration tests in mice[1]. MCL0020 significantly reverses stress-induced anorexia in rats[1].
References	[1]. Chaki S, et al. Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur J Pharmacol. 2003;474(1):95-101.