| Description |
MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM. MCL0020 dose-dependently and significantly attenuates restraint stress-induced anorexia without affecting food intake[1].
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| Related Catalog |
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| Target |
IC50: 11.63 (MC4)
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| In Vitro |
MCL0020 inhibited [125I][N1e4, D-Phe7]α-MSH binding to membranes of COS-1 cells with IC50 values of 11.63[1].
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| In Vivo |
MCL0020 attenuates swim stress-induced anxiogeniclike behavior in light/dark exploration tests in mice[1]. MCL0020 significantly reverses stress-induced anorexia in rats[1].
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| References |
[1]. Chaki S, et al. Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur J Pharmacol. 2003;474(1):95-101.
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