MCL 0020

Modify Date: 2024-01-02 18:18:23

MCL 0020 Structure
MCL 0020 structure
Common Name MCL 0020
CAS Number 475498-26-1 Molecular Weight 609.71800
Density N/A Boiling Point N/A
Molecular Formula C34H39N7O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MCL 0020


MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM. MCL0020 dose-dependently and significantly attenuates restraint stress-induced anorexia without affecting food intake[1].

 Names

Name DPPE fumarate

 MCL 0020 Biological Activity

Description MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM. MCL0020 dose-dependently and significantly attenuates restraint stress-induced anorexia without affecting food intake[1].
Related Catalog
Target

IC50: 11.63 (MC4)

In Vitro MCL0020 inhibited [125I][N1e4, D-Phe7]α-MSH binding to membranes of COS-1 cells with IC50 values of 11.63[1].
In Vivo MCL0020 attenuates swim stress-induced anxiogeniclike behavior in light/dark exploration tests in mice[1]. MCL0020 significantly reverses stress-induced anorexia in rats[1].
References

[1]. Chaki S, et al. Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur J Pharmacol. 2003;474(1):95-101.

 Chemical & Physical Properties

Molecular Formula C34H39N7O4
Molecular Weight 609.71800
Exact Mass 609.30600
PSA 192.29000
LogP 5.06500
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