DC Chemicals Limited
China
Product Name: NIH 10498
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: (-)-cotinine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

486-56-6

486-56-6 structure

Name: Cotinine
Chemical Name: (-)-cotinine
CAS Number: 486-56-6
Molecular Formula: C₁₀H₁₂N₂O
Molecular Weight: 176.215
Catalog: analytical chemistry Standard Forensic and veterinary standards
Create Date: 2018-06-26 23:12:06
Modify Date: 2024-01-02 17:14:05
Cotinine is an alkaloid found in tobacco and is also the predominant metabolite of nicotine, used as a biomarker for exposure to tobacco smoke.

Name	(-)-cotinine
Synonyms	(S)-Cotinine (5S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone (5S)-1-Methyl-5-(pyridin-3-yl)pyrrolidin-2-on T6NJ C- ET5NVTJ A1 &&S Form L-COTININE cotinine (S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone (S)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one (-)-Cotinine,(S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone (−)-Cotinine 2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (5S)- (S)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone (-)-Cotinine S-(-)-Cotinine MFCD00077696 (S)-N-Methyl-2-(3-pyridyl)-5-pyrrolidone Bifemelane hydrochloride EINECS 207-634-9 CREATINE ETHYL ESTER ANALYSIS KIT

Description	Cotinine is an alkaloid found in tobacco and is also the predominant metabolite of nicotine, used as a biomarker for exposure to tobacco smoke.
Related Catalog	Research Areas >> Others Natural Products >> Alkaloid
Target	Human Endogenous Metabolite

Density	1.1±0.1 g/cm3
Boiling Point	316.0±0.0 °C at 760 mmHg
Melting Point	40-42ºC
Molecular Formula	C₁₀H₁₂N₂O
Molecular Weight	176.215
Flash Point	166.7±25.9 °C
Exact Mass	176.094955
PSA	33.20000
LogP	-0.23
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.556
Storage condition	2-8°C
Stability	Stable. Incompatible with strong oxidizing agents. May be heat sensitive - store cold.
Water Solubility	Not miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM), ethanol (50 mg/ml, yielding a clear, faint yellow to yellow solution), methanol and chloroform.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN1925500

CHEMICAL NAME :: Cotinine

CAS REGISTRY NUMBER :: 486-56-6

BEILSTEIN REFERENCE NO. :: 0083099

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H12-N2-O

MOLECULAR WEIGHT :: 176.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1604 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 137,313,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 930 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 137,313,1962

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;Xi: Irritant;
Risk Phrases	R22
Safety Phrases	S36/37
RIDADR	UN 1230 3/PG 2
WGK Germany	3
RTECS	GN1925500
HS Code	2933990090

201230-82-2

1179523-19-3

~44%

54-11-5

486-56-6

Literature: Synlett, , # 9 p. 1413 - 1416

3471-04-3

486-56-6

Literature: Journal of Medicinal Chemistry, , vol. 23, # 8 p. 960 - 962

54-11-5

~50%

486-56-6

Literature: Pharmazie, , vol. 64, # 4 p. 219 - 226

54-11-5

~28%

494-97-3

5980-06-3

486-56-6

Detail

Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 42, # 4 p. 387 - 407

74093-56-4

486-56-6

Literature: Journal of the American Chemical Society, , vol. 81, p. 3951,3954

54-11-5

532-12-7

487-19-4

486-56-6

Literature: Archives of Biochemistry, , vol. 79, p. 124,127

Precursor 4
201230-82-2 3471-04-3 54-11-5 74093-56-4
DownStream 7
487-19-4 34834-67-8 37096-14-3 36508-80-2
3000-74-6 54-11-5 71014-67-0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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