510733-97-8

510733-97-8 structure

Name: ATC 0175 hydrochloride
Chemical Name: N-[4-[[4-(dimethylamino)quinazolin-2-yl]amino]cyclohexyl]-3,4-difluorobenzamide,hydrochloride
CAS Number: 510733-97-8
Molecular Formula: C₂₃H₂₆ClF₂N₅O
Molecular Weight: 461.93500
Catalog: Signaling Pathways GPCR/G Protein MCHR1 (GPR24)
Create Date: 2017-05-19 23:25:29
Modify Date: 2024-01-17 01:47:21
ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders[1].

Name	N-[4-[[4-(dimethylamino)quinazolin-2-yl]amino]cyclohexyl]-3,4-difluorobenzamide,hydrochloride
Synonyms	ATC0175 N-(cis-4-{[4-(Dimethylamino)quinazolin-2-yl]amino}cyclohexyl)-3,4-difluorobenzamide HCl

Description	ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> MCHR1 (GPR24) Research Areas >> Neurological Disease
Target	IC50: 13.5 nM (MCH1R); >10000 nM (MCH2R)[1].
In Vitro	ATC0175 shows affinity for 5-HT2B and 5-HT1A with IC50s of 9.66 and 16.9 nM respectively[1].
In Vivo	ATC0175 (1, 3, 10 mg/kg; p.o.) significantly and dose-dependently reduces immobility time, indicating antidepressant like potential[1].
References	[1]. Chaki S, Yamaguchi J, Yamada H, Thomsen W, Tran TA, Semple G, Sekiguchi Y. ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. CNS Drug Rev. 2005 Winter;11(4):341-52.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335-H413
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
RIDADR	NONH for all modes of transport