ATC 0175 hydrochloride

Modify Date: 2024-01-17 01:47:21

ATC 0175 hydrochloride Structure
ATC 0175 hydrochloride structure
Common Name ATC 0175 hydrochloride
CAS Number 510733-97-8 Molecular Weight 461.93500
Density N/A Boiling Point N/A
Molecular Formula C23H26ClF2N5O Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of ATC 0175 hydrochloride


ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders[1].

 Names

Name N-[4-[[4-(dimethylamino)quinazolin-2-yl]amino]cyclohexyl]-3,4-difluorobenzamide,hydrochloride
Synonym More Synonyms

 ATC 0175 hydrochloride Biological Activity

Description ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders[1].
Related Catalog
Target

IC50: 13.5 nM (MCH1R); >10000 nM (MCH2R)[1].

In Vitro ATC0175 shows affinity for 5-HT2B and 5-HT1A with IC50s of 9.66 and 16.9 nM respectively[1].
In Vivo ATC0175 (1, 3, 10 mg/kg; p.o.) significantly and dose-dependently reduces immobility time, indicating antidepressant like potential[1].
References

[1]. Chaki S, Yamaguchi J, Yamada H, Thomsen W, Tran TA, Semple G, Sekiguchi Y. ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. CNS Drug Rev. 2005 Winter;11(4):341-52.

 Chemical & Physical Properties

Molecular Formula C23H26ClF2N5O
Molecular Weight 461.93500
Exact Mass 461.17900
PSA 70.15000
LogP 5.39300

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335-H413
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
RIDADR NONH for all modes of transport

 Articles1

More Articles
Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists.

J. Pharmacol. Exp. Ther. 313 , 831-839, (2005)

Melanin-concentrating hormone (MCH) is a cyclic peptide produced in the lateral hypothalamus. It has been implicated in a number of physiological processes including feeding behavior, energy balance, ...

 Synonyms

ATC0175
N-(cis-4-{[4-(Dimethylamino)quinazolin-2-yl]amino}cyclohexyl)-3,4-difluorobenzamide HCl