519148-48-2

519148-48-2 structure

Name: CJ 033466
Chemical Name: 5-amino-6-chloro-2-methyl-N-[[1-(2-methylpropyl)piperidin-4-yl]methyl]imidazo[1,2-a]pyridine-8-carboxamide
CAS Number: 519148-48-2
Molecular Formula: C₁₉H₂₈ClN₅O
Molecular Weight: 377.91200
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2017-09-06 02:02:51
Modify Date: 2024-01-14 07:50:00
CJ033466 is a novel and selective 5-HT4 receptor partial agonist with an EC50 of 9 nM and has gastroprokinetic effect[1].

Name	5-amino-6-chloro-2-methyl-N-[[1-(2-methylpropyl)piperidin-4-yl]methyl]imidazo[1,2-a]pyridine-8-carboxamide
Synonyms	UNII-9KUW8W70PJ CJ-033,466 PG-9 maleate

Description	CJ033466 is a novel and selective 5-HT4 receptor partial agonist with an EC50 of 9 nM and has gastroprokinetic effect[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT4 Receptor:9 nM (EC50)
References	[1]. Tadayoshi Mikami, et al. 5-Amino-6-chloro-N-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-alpha]pyridine-8-carboxamide (CJ-033,466), a novel and selective 5-hydroxytryptamine4 receptor partial agonist: pharmacological profile in vitro and gastroprokinetic effect in conscious dogs. J Pharmacol Exp Ther. 2008 Apr;325(1):190-9.

519147-88-7

530-62-1

258345-24-3

519148-48-2

Literature: Uchida, Chikara; Noguchi, Hirohide; Stobie, Alan; Gymer, Geoffrey; Fenwick, David Patent: US2003/92699 A1, 2003 ;

Precursor 2
530-62-1 258345-24-3
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