56990-57-9

56990-57-9 structure

Name: NSC 87877
Chemical Name: (7E)-8-oxo-7-[(6-sulfonaphthalen-2-yl)hydrazinylidene]quinoline-5-sulfonic acid
CAS Number: 56990-57-9
Molecular Formula: C₁₉H₁₃N₃O₇S₂
Molecular Weight: 459.45
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2016-04-12 01:36:39
Modify Date: 2025-08-23 12:24:51
NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2].

Name	(7E)-8-oxo-7-[(6-sulfonaphthalen-2-yl)hydrazinylidene]quinoline-5-sulfonic acid
Synonyms	5-Quinolinesulfonic acid, 8-hydroxy-7-[(E)-2-(6-sulfo-2-naphthalenyl)diazenyl]- 8-Hydroxy-7-[(E)-(6-sulfo-2-naphthyl)diazenyl]-5-quinolinesulfonic acid 8-hydroxy-7-((6-sulfo-2-naphthyl)diazenyl)-5-quinolinesulfonic acid 8-Hydroxy-7-[(E)-(6-sulfo-2-naphthyl)diazenyl]quinoline-5-sulfonic acid 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)- 8-Hydroxy-7-(6-sulfo-naphthalen-2-ylazo)-quinoline-5-sulfonic acid

Description	NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Others
Target	IC50: 0.318 μM (shp2), 0.355 μM (shp1)[1].
References	[1]. Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70. [2]. Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5.