62252-26-0

62252-26-0 structure

Name: JLK 6
Chemical Name: 7-Amino-4-chloro-3-methoxy-1H-2-benzopyran
CAS Number: 62252-26-0
Molecular Formula: C₁₀H₈ClNO₃
Molecular Weight: 225.62800
Catalog: Research Areas Neurological Disease
Create Date: 2018-12-24 18:18:54
Modify Date: 2024-01-13 16:36:02
JLK-6 markedly reduce the production of amyloid β-peptide (Aβ) by amyloid-β Precursor protein (APP) expressing HEK293 cells by affecting the γ-secretase cleavage of APP, with no effect on the cleavage of the Notch receptor[1].

Name	7-Amino-4-chloro-3-methoxy-1H-2-benzopyran
Synonyms	7-amino-3-methoxy-4-chloroisocoumarin 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN 7-Amino-4-chlor-3-methoxyisocumarin 3-methoxy-4-chloro-7-aminoisocoumarin 7-amino-4-chloro-3-methoxy-isochromen-1-one

Description	JLK-6 markedly reduce the production of amyloid β-peptide (Aβ) by amyloid-β Precursor protein (APP) expressing HEK293 cells by affecting the γ-secretase cleavage of APP, with no effect on the cleavage of the Notch receptor[1].
Related Catalog	Research Areas >> Neurological Disease
References	[1]. Marine Peuchmaur, et al. Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein. Bioorg Med Chem. 2013 Feb 15;21(4):1018-29.

Hazard Codes	Xi
HS Code	2932999099

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%